Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Abba, J."'
Publikováno v:
Journal of Molecular Neuroscience. 55:644-652
Chronic sleep fragmentation (SF), common in patients with sleep apnea, correlates with the development of obesity. We hypothesized that SF differentially affects neurobehavior in lean wild-type (WT) and obese pan-leptin receptor knockout (POKO) mice
Publikováno v:
Journal of Molecular Neuroscience. 49:523-530
Both proconvulsive and anticonvulsive roles of leptin have been reported, suggesting cell-specific actions of leptin in different models of seizure and epilepsy. The goal of our study was to determine the regulation and function of astrocytic leptin
Publikováno v:
Journal of Molecular Neuroscience. 49:446-456
The detrimental role of leptin in experimental autoimmune encephalomyelitis (EAE) is opposite to its neuroprotective role in other neuropathologies. We hypothesize that a shifted cellular distribution of leptin receptors underlies the differential ef
Publikováno v:
Journal of Molecular Neuroscience. 43:478-484
We tested the hypothesis that astrocytic activity modulates neuronal uptake and signaling of leptin in the adult-onset obese agouti viable yellow (A vy) mouse. In the immunohistochemical study, A vy mice were pretreated with the astrocyte metabolic i
Autor:
Franz Halberg, Hung Hsuchou, Barry Robert, Finla Chatu, Weihong Pan, Xiaojun Wu, Germaine G Cornelissen-Guillaume, Yan Zhang, Reas S. Khan, Abba J. Kastin
Publikováno v:
Journal of Molecular Neuroscience. 43:412-423
We have shown that TNFα specifically activates the interleukin-15 (IL15) system in cerebral endothelial cells composing the blood-brain barrier. To determine the functions of cerebral IL15 signaling in inflammation, we first treated mice with lipopo
Publikováno v:
Journal of Molecular Neuroscience. 33:232-238
Cooperativity among ingestive peptides reflects attempts by the body to finely control its weight. Urocortin, like leptin, is a potent suppressor of food intake, and they interact at the blood-brain barrier (BBB). After injection into the hypothalamu
Publikováno v:
Journal of Molecular Neuroscience. 31:171-181
Urocortin, a potent peptide inhibitor of feeding behavior, can enter the brain from blood by leptin-facilitated permeation across the blood-brain barrier. Here, we show in cultured RBE4 cerebral microvessel endothelial cells that urocortin endocytosi
Publikováno v:
Journal of Molecular Neuroscience. 32:80-89
The blood-brain barrier (BBB), a communicating interface for inflammation, transports cytokines through its endothelial cells. This study shows how tumor necrosis factor alpha (TNF) regulates the expression of the leukemia inhibitor factor receptor (
Publikováno v:
Journal of Molecular Neuroscience. 21:43-48
Transforming growth factor-beta (TGF-beta) from the periphery can cross the disrupted blood-brain barrier (BBB) to exert neuroprotective effects on the brain. Here, we quantify its permeation across the normal mouse BBB. By high-performance liquid ch
Publikováno v:
Journal of Molecular Neuroscience. 21:173-184
Tumor necrosis factor (TNF-alpha) is involved in the inflammation and tissue regeneration occurring after spinal cord injury (SCI). This study tests the specific role of p55 and p75 receptors in mediating the transport of TNF-alpha across the blood-s