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pro vyhledávání: '"Evan R. Simpson"'
Autor:
Kristy A. Brown, Evan R. Simpson
Publikováno v:
Journal of molecular endocrinology. 51(3)
Obesity is now recognised to be an inflammatory condition in which dysregulated metabolism plays an integral role. Inflammatory mediators regulate aromatase expression in the human breast as one mechanism whereby they increase the risk of breast canc
Publikováno v:
Journal of molecular endocrinology. 32(2)
A number of clinical studies have highlighted the importance of estrogen in bone growth and maintenance in men and postmenopausal women. In these instances, estrogen is synthesized locally within bone tissue by aromatase, encoded by the CYP19 gene. T
Autor:
Evan R. Simpson
Publikováno v:
Journal of molecular endocrinology. 25(2)
Our understanding of the role of oestrogens in both males and females has expanded greatly in recent years. Hitherto unanticipated roles have emerged that question the very definitions of the terms ‘oestrogen’ and ‘androgen’ as they are curre
Publikováno v:
Journal of molecular endocrinology. 6(2)
To investigate the effects of sex hormones on 5α-reductase, we examined 5α-reductase mRNA content and enzyme activity in the adrenal cortex of peripubertal male and female rats. In male rats, the influence of castration or hormone-replacement treat
Autor:
D. Stirling, Ronald R. Magness, E. D. Lephart, Michael J. McPhaul, Kevin J. Doody, Evan R. Simpson, M C Lorence
Publikováno v:
Journal of molecular endocrinology. 6(2)
We have examined the levels of expression of mRNA species encoding cholesterol side-chain cleavage cytochrome P-450 (P-450scc), 17α-hydroxylase cytochrome P-450 (P-45017α ), aromatase cytochrome P-450 (P-450AROM) and 3β-hydroxy-steroid dehydrogena