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Autor:
Yunping Wang, Jing Wu, Jiandong Bao, Liying Wu, Li Zhang, Xian Cheng, Shichen Xu, Huixin Yu, Xiaowen Wang
Publikováno v:
Journal of Molecular Cell Biology
Anaplastic thyroid cancer (ATC) is a rare but highly lethal disease. ATCs are resistant to standard therapies and are extremely difficult to manage. The stepwise cell dedifferentiation results in the impairment of the iodine-metabolizing machinery an
Autor:
Jinghe Zhang, Hong Zhao, Binqing Fu, Peng Peng, Zhigang Tian, Dongyao Wang, Dong Wang, Yiqing Shen, Xiaodong Mei, Qi Zhu, Xiaohu Zheng, Min Huang, Xianxiang Chen, Guiqiang Wang, Wuxiang Guan, Yonggang Zhou
Publikováno v:
Journal of Molecular Cell Biology
Background: The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has gradually become a global public health crisis. Some patients who have recovered from COVID-19 subsequently tested positi
Publikováno v:
Journal of Molecular Cell Biology
The cyclic GMP‒AMP synthase (cGAS)‒stimulator of interferon genes (STING) signaling pathway senses the presence of cytosolic DNA and, in turn, triggers downstream signaling to induce the expression of inflammatory and type I interferon genes in i
Autor:
Wenwen Wang, Xuebiao Yao, Xiaoyu Song, Dongmei Wang, Xing Liu, Zhen Dou, Xiwei Wang, Manjuan Zhang, Fengrui Yang
Publikováno v:
Journal of Molecular Cell Biology
Chromosome segregation in mitosis is orchestrated by the dynamic interactions between the kinetochore and spindle microtubules. Our recent studies show that mitotic motor CENP-E cooperates with SKAP and forms a link between kinetochore core MIS13 com
Autor:
Congting Guo, Ying Zhao
Publikováno v:
Journal of Molecular Cell Biology
Autor:
McKay Mullen, Fengrui Yang, Jun Cao, Yang Cao, Xu Liu, Gee Young Lee, Tao Li, William Yao, Zhihong Yang, Jiahai Zhang, Kela Johnson, Felix Aikhionbare, Yong Chen, Xinjiao Gao, Dongmei Wang, Xia Ding, Hadiyah-Nicole Green, Xing Liu, Xuebiao Yao
Publikováno v:
Journal of Molecular Cell Biology
Publikováno v:
Journal of Molecular Cell Biology
The prevailing coronavirus disease-19 (COVID-19) caused by a novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has presented some neurological manifestations including hyposmia, hypogeusia, headache, stroke, encephalitis, Guillain–Ba
Publikováno v:
Journal of Molecular Cell Biology
The neuromuscular junction (NMJ), a peripheral synaptic connection between motoneurons and skeletal muscle fibers, controls movement. Dysregulation of NMJs has been implicated in various motor disorders. Because of their large size and easy accessibi
Publikováno v:
Journal of Molecular Cell Biology
The centrosome is a membrane-less organelle consisting of a pair of barrel-shaped centrioles and pericentriolar material and functions as the major microtubule-organizing center and signaling hub in animal cells. The past decades have witnessed the f
Autor:
Xihua Lin, Daniel Turunen Eserberg, Linghua Zhu, Erik Matro, Yi-ping Zhu, Fang Wu, Nan Zhang, Weiwei Gui
Publikováno v:
Journal of Molecular Cell Biology
Extreme hypoxia is among the most prominent pathogenic features of pancreatic cancer (PC). Both the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) and hypoxic inducible factor-1α (HIF-1α) are highly expressed in PC patient