Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Chunyu Wang"'
Autor:
Jing Zhao, Xinyue Liu, Alan Blayney, Yumeng Zhang, Lauren Gandy, Paige Olivia Mirsky, Nathan Smith, Fuming Zhang, Robert J. Linhardt, Jianhan Chen, Christopher Baines, Stewart N. Loh, Chunyu Wang
Publikováno v:
Journal of molecular biology. 434(9)
Mitochondrial permeability transition pore (mPTP) plays crucial roles in cell death in a variety of diseases, including ischemia/reperfusion injury in heart attack and stroke, neurodegenerative conditions, and cancer. To date, cyclophilin D is the on
Publikováno v:
Journal of Molecular Biology. 400:755-767
Inteins mediate protein splicing, which has found many applications in biotechnology and protein engineering. A single valine-to-leucine mutation (V67L) can globally enhance splicing and related cleavage reactions in minimized Mycobacterium tuberculo
Autor:
Yilin Yan, Chunyu Wang
Publikováno v:
Journal of Molecular Biology. 369:909-916
Abeta40 and Abeta42 are the predominant Abeta species in the human body. Toxic Abeta42 oligomers and fibrils are believed to play a key role in causing Alzheimer's disease (AD). However, the role of Abeta40 in AD pathogenesis is not well established.
Autor:
Chunyu Wang, Yilin Yan
Publikováno v:
Journal of Molecular Biology. 364:853-862
Abeta40 and Abeta42 are the major forms of amyloid beta peptides (Abeta) in the brain. Although Abeta42 differs from Abeta40 by only two residues, Abeta42 is much more prone to aggregation and more toxic to neurons than Abeta40. To probe whether dyna
Publikováno v:
Journal of Molecular Biology. 342:525-537
ATP-binding cassette (ABC) transporters move solutes across membranes and are associated with important diseases, including cystic fibrosis and multi-drug resistance. These molecular machines are energized by their charateristic ABC modules, molecula
Publikováno v:
Journal of Molecular Biology. 304:497-505
Changes in the molecular conformation of proteins can result from a variety of perturbations, and can play crucial roles in the regulation of biological activity. A new solution NMR method has been applied to monitor ligand-induced changes in hydroge
Autor:
Nikolaos G. Sgourakis, Christos Boutsidis, Myrna Merced-Serrano, Petros Drineas, Chunyu Wang, Angel E. Garcia, Zheming Du
Publikováno v:
Journal of molecular biology. 405(2)
Aβ(1–42) is the highly pathologic isoform of amyloid-β, the peptide constituent of fibrils and neurotoxic oligomers involved in Alzheimer's disease. Recent studies on the structural features of Aβ in water have suggested that the system can be d
Autor:
Peter C. Maloney, William B. Guggino, Kathleen S. Molnar, Diana R. Wetmore, Patricia C. Weber, Yoshitomo Hamuro, John F. Hunt, K. Conners, H.A. Lewis, F. Lu, J.M. Sauder, Stephen J. Coales, X. Zhao, M.C. Kearins, Chunyu Wang
Publikováno v:
Journal of molecular biology. 396(2)
The DeltaF508 mutation in nucleotide-binding domain 1 (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR) is the predominant cause of cystic fibrosis. Previous biophysical studies on human F508 and DeltaF508 domains showed only l
Publikováno v:
Journal of molecular biology. 368(5)
The role of peptides Abeta40 and Abeta42 in the early pathogenesis of Alzheimer's disease (AD) is frequently emphasized in the literature. It is known that Abeta42 is more prone to aggregation than Abeta40, even though they differ in only two (IA) am
Publikováno v:
Journal of molecular biology. 313(4)
The Src homology 3 (SH3) domain of pp60 c-src (Src) plays dual roles in signal transduction, through stabilizing the repressed form of the Src kinase and through mediating the formation of activated signaling complexes. Transition of the Src SH3 doma