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Autor:
I-Wen Wang, Keith L. March, Mark W. Turrentine, Jianyun Liu, Susan R. Scott, Chandan K. Sen, Kanhaiya Singh, Meijing Wang
Publikováno v:
J Mol Cell Cardiol
Background Heart transplantation, a life-saving approach for patients with end-stage heart disease, is limited by shortage of donor organs. While prolonged storage provides more organs, it increases the extent of ischemia. Therefore, we seek to under
Publikováno v:
J Mol Cell Cardiol
The inositol 1,4,5-trisphosphate receptor (InsP(3)R) is up-regulated in patients with atrial fibrillation (AF) and InsP(3)-induced Ca(2+) release (IICR) is linked to pro-arrhythmic spontaneous Ca(2+) release events. Nevertheless, knowledge of the phy
Autor:
Tina C. Wan, Alexandra L. Purdy, John Lough, Xinrui Wang, Katherine R. Kulik, Michaela Patterson, Amelia Lauth, John A. Auchampach
Publikováno v:
J Mol Cell Cardiol
Injury from myocardial infarction (MI) and consequent post-MI remodeling is accompanied by massive loss of cardiomyocytes (CM), a cell type critical for contractile function that is for all practical purposes non-regenerable due to its profound state
Publikováno v:
Journal of Molecular and Cellular Cardiology. 163:133-146
The integrity of the endothelial barrier is required to maintain vascular homeostasis and fluid balance between the circulatory system and surrounding tissues and to prevent the development of vascular disease. However, the origin of the newly develo
Publikováno v:
J Mol Cell Cardiol
Rupture of aortic aneurysm and dissection (AAD) remains a leading cause of death. Progressive smooth muscle cell (SMC) loss is a crucial feature of AAD that contributes to aortic dysfunction and degeneration, leading to aortic aneurysm, dissection, a
Autor:
Johannes Backs, Sebastian Guttzeit
Publikováno v:
Journal of Molecular and Cellular Cardiology. 162:53-61
Epigenetic modifications, such as histone or DNA modifications are key regulators of gene transcription and changes are often associated with maladaptive processes underlying cardiovascular disease. Epigenetic regulators therefore likely play a cruci
Autor:
Victor Alencar-Almeida, Samantha K Swift, Aria Kenarsary, Michael A. Flinn, Michaela Patterson, Caitlin C. O'Meara, Santiago Alvarez-Argote, Samantha J. Paddock
Publikováno v:
J Mol Cell Cardiol
Neonatal heart regeneration depends on proliferation of pre-existing cardiomyocytes, yet the mechanisms driving regeneration and cardiomyocyte proliferation are not comprehensively understood. We recently reported that the anti-inflammatory cytokine,
Autor:
Vinayak Gupta, Poovitha Sundar, Nitish R. Mahapatra, Bhargavi Natarajan, S Santosh Reddy, Vikas Arige, Abrar A. Khan, Manoj Kumar Barthwal
Publikováno v:
Journal of Molecular and Cellular Cardiology. 158:140-152
3-Hydroxy-3-methyl glutaryl-coenzyme A reductase (Hmgcr) encodes the rate-limiting enzyme in the cholesterol biosynthesis pathway. The regulation of Hmgcr in rat models of genetic hypertension (viz. Spontaneously Hypertensive Rat [SHR] and its normot
Autor:
Slava Bekker, Mao Tsuen Jeng, Heike Wulff, Colleen E. Clancy, Van A. Ngo, Pei Chi Yang, Kazuharu Furutani, James C. Fettinger, Vladimir Yarov-Yarovoy, Vikrant Singh, Igor Vorobyov, Sergei Y. Noskov, Jon T. Sack, Kevin R. DeMarco, John R. D. Dawson
Publikováno v:
Journal of Molecular and Cellular Cardiology. 158:163-177
Drug isomers may differ in their proarrhythmia risk. An interesting example is the drug sotalol, an antiarrhythmic drug comprising d- and l- enantiomers that both block the hERG cardiac potassium channel and confer differing degrees of proarrhythmic
Autor:
Mitchell Simon, Donald M. Bers, Sonya Baidar, Robyn T. Rebbeck, Christopher Y. Ko, Razvan L. Cornea
Publikováno v:
Journal of molecular and cellular cardiology
Persistent over-activation of CaMKII (Calcium/Calmodulin-dependent protein Kinase II) in the heart is implicated in arrhythmias, heart failure, pathological remodeling, and other cardiovascular diseases. Several post-translational modifications (PTMs