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Publikováno v:
J Mol Cell Cardiol
The inositol 1,4,5-trisphosphate receptor (InsP(3)R) is up-regulated in patients with atrial fibrillation (AF) and InsP(3)-induced Ca(2+) release (IICR) is linked to pro-arrhythmic spontaneous Ca(2+) release events. Nevertheless, knowledge of the phy
Autor:
Johannes Backs, Sebastian Guttzeit
Publikováno v:
Journal of Molecular and Cellular Cardiology. 162:53-61
Epigenetic modifications, such as histone or DNA modifications are key regulators of gene transcription and changes are often associated with maladaptive processes underlying cardiovascular disease. Epigenetic regulators therefore likely play a cruci
Autor:
Vinayak Gupta, Poovitha Sundar, Nitish R. Mahapatra, Bhargavi Natarajan, S Santosh Reddy, Vikas Arige, Abrar A. Khan, Manoj Kumar Barthwal
Publikováno v:
Journal of Molecular and Cellular Cardiology. 158:140-152
3-Hydroxy-3-methyl glutaryl-coenzyme A reductase (Hmgcr) encodes the rate-limiting enzyme in the cholesterol biosynthesis pathway. The regulation of Hmgcr in rat models of genetic hypertension (viz. Spontaneously Hypertensive Rat [SHR] and its normot
Autor:
Slava Bekker, Mao Tsuen Jeng, Heike Wulff, Colleen E. Clancy, Van A. Ngo, Pei Chi Yang, Kazuharu Furutani, James C. Fettinger, Vladimir Yarov-Yarovoy, Vikrant Singh, Igor Vorobyov, Sergei Y. Noskov, Jon T. Sack, Kevin R. DeMarco, John R. D. Dawson
Publikováno v:
Journal of Molecular and Cellular Cardiology. 158:163-177
Drug isomers may differ in their proarrhythmia risk. An interesting example is the drug sotalol, an antiarrhythmic drug comprising d- and l- enantiomers that both block the hERG cardiac potassium channel and confer differing degrees of proarrhythmic
Autor:
Mitchell Simon, Donald M. Bers, Sonya Baidar, Robyn T. Rebbeck, Christopher Y. Ko, Razvan L. Cornea
Publikováno v:
Journal of molecular and cellular cardiology
Persistent over-activation of CaMKII (Calcium/Calmodulin-dependent protein Kinase II) in the heart is implicated in arrhythmias, heart failure, pathological remodeling, and other cardiovascular diseases. Several post-translational modifications (PTMs
Publikováno v:
Journal of Molecular and Cellular Cardiology. 153:95-103
Suppression of the cardiac sodium channel NaV1.5 leads to fatal arrhythmias in ischemic heart disease (IHD). However, the transcriptional regulation of NaV1.5 in cardiac ischemia is still unclear. Our studies are aimed to investigate the expression o
Autor:
Li-Na Xu, Xuexiang Cha, Xue-Ling Su, Sumra Komal, Shu-Hui Wang, Mingxi Zang, Shengna Han, Yu Yao, Cheng Chang, Li-Rong Zhang, Xinshou Ouyang
Publikováno v:
Journal of Molecular and Cellular Cardiology. 149:82-94
Inflammasome-promoted sterile inflammation following cardiac damage is critically implicated in heart dysfunction after myocardial infarction (MI). Glycogen synthase kinase-3 (GSK-3β) is a prominent mediator of the inflammatory response, and high GS
Publikováno v:
J Mol Cell Cardiol
The sarcomere is the functional unit of cardiac muscle, essential for normal heart function. To date, it has not been possible to study, in real time, thin filament-based activation dynamics in live cardiac muscle. We report here results from a cardi
Autor:
Qiang Chai, Tian-You Ling, Li Xiaoyan, Zhen-Ye Zhang, Fu Yi, Ru-Xing Wang, Xin Ma, L L Qian, Ning Wang, Ling-Feng Miao, Min Pan, Ying Wu, Liu Xiaoyu, Shipeng Dang
Publikováno v:
Journal of Molecular and Cellular Cardiology. 145:14-24
Glucose fluctuations may contribute to large conductance calcium activated potassium (BK) channel dysfunction. However, the underlying mechanisms remain elusive. The aim of this study was to investigate the molecular mechanisms involved in BK channel
Autor:
Jiangang Gao, Cheng Zhang, Chang-Han Ouyang, Yuanyuan Sun, Qing Min, Guangqing Cao, Wencheng Zhang, Xiao Meng, Jiliang Wu, Tianran Zhang
Publikováno v:
Journal of Molecular and Cellular Cardiology. 142:39-52
Vascular calcification is a pathological process closely related to atherosclerosis, diabetic vascular diseases, vascular injury, hypertension, chronic kidney disease and aging. Lethal giant larvae 1 (LGL1) is known as a key regulator of cell polarit