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pro vyhledávání: '"Xiaoliang Jin"'
Autor:
Le Zhen, Xiao-Wen Yang, Liang Dai, Yu Shengqi, Guangji Wang, Xiaoliang Jin, Lan Yao, Haoliang Yuan, Xiaoan Wen, Hongbin Sun, Wenfeng Zhao
Publikováno v:
Journal of medicinal chemistry. 60(14)
Resistant HCV variants carrying NS5B S282T mutation confer reduced sensitivity to sofosbuvir, the sole marketed NS5B polymerase inhibitor. On the basis of the finding that 2'-α-F-2'-β-C-methylcytidine 5'-triphosphate (8) was more potent than sofosb