Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Joshi A"'
Autor:
Pritam Maity, Joydeep Chatterjee, Kiran T. Patil, Sahil Arora, Madhurendra K. Katiyar, Manvendra Kumar, Amirreza Samarbakhsh, Gaurav Joshi, Priyadeep Bhutani, Manoj Chugh, Navnath S. Gavande, Raj Kumar
Publikováno v:
Journal of Medicinal Chemistry. 66:3135-3172
Akademický článek
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Autor:
Alexander M. Taylor, Chris Bailey, Lisa D. Belmont, Robert Campbell, Nico Cantone, Alexandre Côté, Terry D. Crawford, Richard Cummings, Kevin DeMent, Martin Duplessis, Megan Flynn, Andrew C. Good, Hon-Ren Huang, Shivangi Joshi, Yves Leblanc, Jeremy Murray, Christopher G. Nasveschuk, Adrianne Neiss, Florence Poy, F. Anthony Romero, Peter Sandy, Yong Tang, Vickie Tsui, Laura Zawadzke, Robert J. Sims, James E. Audia, Steven F. Bellon, Steven R. Magnuson, Brian K. Albrecht, Andrea G. Cochran
Publikováno v:
Journal of medicinal chemistry. 65(16)
Bromodomains are acetyllysine recognition domains present in a variety of human proteins. Bromodomains also bind small molecules that compete with acetyllysine, and therefore bromodomains have been targets for drug discovery efforts. Highly potent an
Akademický článek
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Autor:
Shreyas Deshpande, Rashmi Talwar, Ganesh Navinchandra Gote, Jayasagar Gundu, Rupali Vyawahare, Shashikant Pawar, Akshaya Wagh, Talha Khan, Anil Kalia, Venkata P. Palle, Usha Dhayagude, M. K. Singh, Pradeep Patil, Ganesh Chaure, Praveen Kumar Gupta, Amit Das, Vijay Kanoje, Sharad Sharma, Vidya Ramdas, Vinod Patil, Rajesh Yeshodharan, Prashant B. Nigade, Dipak Modi, Dnyaneshwar Warude, Dilip Pandey, Jagadeesh Daler, Mahammad Azhar, Arun Nayak, Sneha Joshi, Sudipto Das, Rajender Kumar Kamboj, Javed S Shaikh, Maneesh Mehta, Deepak Sahebrao Walke, Rajesh V. Gupta, Himani Pareek, Kumar V S Nemmani, Parag Joshi, Mahip Verma, Vinod Mali, Laxmikant Datrange, Santosh Parkale, Rajesh Loriya, Vaibhav Kalhapure, Geetika Sharma, Ravindra R. Pal, Sagar Budhe, Gautam Agarwal, Sachin Suravase, Sagar Darekar, Mark G. Bock, Advait Arun Joshi, Moloy Banerjee, Smita Bhoskar, Amitesh Kishore, Dhananjay Bakhle
Publikováno v:
Journal of Medicinal Chemistry. 63:6107-6133
Voltage-gated sodium channel NaV1.7 is a genetically validated target for pain. Identification of NaV1.7 inhibitors with all of the desired properties to develop as an oral therapeutic for pain has been a major challenge. Herein, we report systematic
Akademický článek
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Autor:
John A. Morrow, Robert Mazzola, Cristian Salinas, Eric D. Hostetler, Stefania Risso, Fiona Thomson, Tjerk Bueters, Nicholas B. Hastings, Jenny Wai, Sony Agrawal, Liza Gantert, Brian C. Magliaro, Paul McQuade, Zhizhen Zeng, Marie A. Holahan, David Hesk, Melissa Egbertson, Jeffrey W. Schubert, Ling Tong, Robert Gomez, Jongrock Kong, Aniket Joshi, Frederick J. Monsma, David M. Tellers, Kristen L.G. Jones, Jason M. Uslaner, Jing Liao, Patricia Miller, Michelle Smith, Oleg Selyutin, Kerry Riffel, Xiaolei Gao, Scott T. Harrison, Zhaoyang Meng, James Mulhearn, Michael Man-Chu Lo, Wenping Li, Michael T. Rudd, Barbara Hanney, Mona Purcell, Jianming Bao, Hyking Haley
Publikováno v:
Journal of Medicinal Chemistry. 63:2411-2425
The measurement of receptor occupancy (RO) using positron emission tomography (PET) has been instrumental in guiding discovery and development of CNS directed therapeutics. We and others have investigated muscarinic acetylcholine receptor 4 (M4) posi
Autor:
Pratima Srivastava, Arnab Goswami, Amruta Dash, Deepak Sahebrao Walke, Gautam Agarwal, Dipak Modi, Moloy Banerjee, Rajender Kumar Kamboj, Rashmi Talwar, Hemant Kumar, Falguni Modi, Advait Arun Joshi, Aruna Sivaram, Venkata P. Palle, Vinod Patil, Lakshmi Narasimham, Vidya Ramdas, Ganesh Navinchandra Gote, Sharad Sharma, M. K. Singh, Sadanand Mallurwar, Prashant B. Nigade, Sandip Kuldharan, Prashant Borhade, Rajesh Loriya, Maneesh Mehta, Jayasagar Gundu, Apparao Bommakanti, Usha Dhayagude, Amit Kumar Das
Publikováno v:
Journal of Medicinal Chemistry. 62:10563-10582
The identification of a novel class of potent pan-genotypic NS5A inhibitors with good pharmacokinetic profile suitable for potential use in treating HCV infections is disclosed here. The present series of compounds are with less complex tricyclic cen
Autor:
Gaurav Joshi, Michael Heuser, Anuhar Chaturvedi, Santoshkumar N. Patil, Sahil Arora, Raj Kumar
Publikováno v:
Journal of medicinal chemistry. 65(2)
The allosteric regulation of pyruvate kinase M2 (PKM2) affects the switching of the PKM2 protein between the high-activity and low-activity states that allow ATP and lactate production, respectively. PKM2, in its low catalytic state (dimeric form), i
Autor:
Juan Zhou, Shuo Feng, Xiaoli Wu, Tse-Shao Chang, Xiaoqing Meng, Bishnu P. Joshi, Zhao Li, Lili Zhao, Eun-Young Choi, Thomas D. Wang, Jiye Zhu
Publikováno v:
J Med Chem
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is rising steadily in incidence, and more effective methods are needed for early detection and image-guided surgery. Glypican-3 (GPC3) is a cell surface biomarker that is overexpressed in early-stage