Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Hironori Hayashi"'
Autor:
Arun K. Ghosh, Jacqueline N. Williams, Rachel Y. Ho, Hannah M. Simpson, Shin-ichiro Hattori, Hironori Hayashi, Johnson Agniswamy, Yuan-Fang Wang, Irene T. Weber, Hiroaki Mitsuya
Publikováno v:
Journal of Medicinal Chemistry. 61:9722-9737
We have designed, synthesized, and evaluated a new class of potent HIV-1 protease inhibitors with novel bicyclic oxazolidinone derivatives as the P2 ligand. We have developed an enantioselective synthesis of these bicyclic oxazolidinones utilizing a
Autor:
Kristof Glauninger, Hironori Hayashi, Hiroaki Mitsuya, Arun K. Ghosh, Heather L. Osswald, Irene T. Weber, Johnson Agniswamy, Manabu Aoki, Yuan-Fang Wang
Publikováno v:
Journal of medicinal chemistry. 59(14)
A series of potent HIV-1 protease inhibitors with a lipophilic adamantyl P1 ligand have been designed, synthesized, and evaluated. We have developed an enantioselective synthesis of adamantane-derived hydroxyethylamine isosteres utilizing Sharpless a
Autor:
Heather L. Osswald, Hiroaki Mitsuya, Irene T. Weber, Venkat Reddy Sheri, Yuan-Fang Wang, Hironori Hayashi, Luke A. Kassekert, Arun K. Ghosh, Shujing Chen, Manabu Aoki, Johnson Agniswamy, Cuthbert D. Martyr
Publikováno v:
Journal of medicinal chemistry. 58(17)
Structure-based design, synthesis, and biological evaluation of a series of very potent HIV-1 protease inhibitors are described. In an effort to improve backbone ligand-binding site interactions, we have incorporated basic-amines at the C4 position o
Autor:
Ghosh, Arun K., Osswald, Heather L., Glauninger, Kristof, Agniswamy, Johnson, Yuan-Fang Wang, Hironori Hayashi, Manabu Aoki, Weber, Irene T., Hiroaki Mitsuya
Publikováno v:
Journal of Medicinal Chemistry; Jul2016, Vol. 59 Issue 14, p6826-6837, 12p
Autor:
Ghosh, Arun K., Martyr, Cuthbert D., Osswald, Heather L., Sheri, Venkat Reddy, Kassekert, Luke A., Shujing Chen, Agniswamy, Johnson, Yuan-Fang Wang, Hironori Hayashi, Aoki, Manabu, Weber, Irene T., Hiroaki Mitsuya
Publikováno v:
Journal of Medicinal Chemistry; Sep2015, Vol. 58 Issue 17, p6994-7006, 13p