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Autor:
Chang-Cui Zhou, Rui Ling, Pei-Xi Hong, Yi Kang, Qing-Rong Qi, Xing-Hai Song, Liang-Quan Liu, Jun Yang
Publikováno v:
Journal of Medicinal Chemistry. 63:7857-7866
In this work, a series of water-soluble propofol prodrugs were synthesized, and their propofol release rate and pharmacodynamic characteristics were measured. We found that inserting glycolic acid as a linker between propofol and the cyclic amino aci