Zobrazeno 1 - 7
of 7
pro vyhledávání: '"59"'
Autor:
Jonathan Maher, F. Anthony Romero, Samir Kharbanda, Mark Merchant, Ivana Yen, Yingjie Li, Edna F. Choo, Jiangpeng Liao, Xiaocang Wei, Kwong Wah Lai, Karen E. Gascoigne, Richard D. Cummings, Hariharan Jayaram, Thomas Hunsaker, Steven F. Bellon, Jian Wang, Cameron L. Noland, Brian K. Albrecht, Ying Jiang, Jeremy Murray, Susan Kaufman, Kerry L. Spillane, Florence Poy, Zhaowu Xu, Fei Wang, James R. Kiefer, Laura Zawadzke, Zhongguo Chen, Alexander M. Taylor, Andrew R. Conery, Xiaoyu Zhu, Wenfeng Liu, Eneida Pardo, Alexandre Côté, Andrea G. Cochran, Vickie Tsui, Steven Magnuson, Terry Crawford, Maureen Beresini, Emily Chan, Kevin X. Chen, Gladys de Leon Boenig, Justin Ly, Tracy Kleinheinz, Zhongya Xu
Publikováno v:
Journal of medicinal chemistry. 59(23)
The single bromodomain of the closely related transcriptional regulators CBP/EP300 is a target of much recent interest in cancer and immune system regulation. A co-crystal structure of a ligand-efficient screening hit and the CBP bromodomain guided i
Publikováno v:
Journal of Medicinal Chemistry. 48:457-465
A molecular modeling study was carried out to develop a predictive model for combretastatin-like analogues populating the colchicine-binding site of beta-tubulin. A series of compounds built around a framework including two aromatic groups linked by
Autor:
William R. Wilson, Robert F. Anderson, Dianne M. Ferry, Nuala A. Helsby, Alison Hogg, Shangjin Yang, Brian D. Palmer, Graham J. Atwell, William A. Denny, Susan M. Pullen
Publikováno v:
Journal of Medicinal Chemistry. 47:3295-3307
The 5-aziridinyl-2,4-dinitrobenzamide CB 1954 is a substrate for the oxygen-insensitive nitroreductase (NTR) from E. coli and is in clinical trial in combination with NTR-armed adenoviral vectors in a GDEPT protocol; CB 1954 is also of interest for s
Autor:
Alessia Salvador, Paola Barraja, Daniela Vedaldi, Gaetano Dattolo, Giampietro Viola, Alessandra Montalbano, Girolamo Cirrincione, Giuseppe Basso, Annamaria Martorana, Francesco Dall'Acqua, Patrizia Diana
Publikováno v:
Journal of medicinal chemistry. 51(8)
Isoindoloquinoxalines 4 and 5 were obtained by refluxing 2-(2'-aminoaryl)-1-cyanoisoindoles 3a- e in acetic or formic acid. All derivatives were screened by the National Cancer Institute (Bethesda, MD) for the in vitro one dose primary anticancer ass
Autor:
Madeleine Blanc, Luc Choisnard, Denis Wouessidjewe, Edwige Nicolle, Pierre-Alain Carrupt, Annabelle Gèze, Eva-Laure Matera, Ahcène Boumendjel, Charles Dumontet, Julien Boccard
Publikováno v:
Journal of Medicinal Chemistry, Vol. 51, No 7 (2008) pp. 2307-10
A series of 59 chalcones was prepared and evaluated for the antimitotic effect against K562 leukemia cells. The most active chalcones were evaluated for their antiproliferative activity against a panel of 11 human and murine cell cancer lines. We fou
Autor:
Dennis Powell, Rolf Paul, Hallett William A, Ron Citarella, Lee M. Greenberger, Minu Dutia, Dan Maarten Berger
Publikováno v:
Journal of medicinal chemistry. 42(12)
A series of 59 alpha-aryl-alpha-thioether-alkyl, -alkanenitrile, and -alkanecarboxylic acid methyl ester tetrahydroisoquinoline and isoindoline derivatives (15a-48) were synthesized and evaluated as multidrug resistance (MDR) reversal agents. The com
Autor:
Raymond J. Bergeron, Hua Yao, Curt O. Zimmerman, Ralf Müller, William R. Weimar, Bruce H. McCosar, Richard E. Smith
Publikováno v:
Journal of medicinal chemistry. 41(20)
The availability of synthetic hypusine and deoxyhypusine has made it possible to develop analytical methods which allow for the measurement of these compounds in various tissues. The methods involve dansylation of extracts from the pellet remaining a