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Autor:
Dennis Powell, Rolf Paul, Hallett William A, Ron Citarella, Lee M. Greenberger, Minu Dutia, Dan Maarten Berger
Publikováno v:
Journal of medicinal chemistry. 42(12)
A series of 59 alpha-aryl-alpha-thioether-alkyl, -alkanenitrile, and -alkanecarboxylic acid methyl ester tetrahydroisoquinoline and isoindoline derivatives (15a-48) were synthesized and evaluated as multidrug resistance (MDR) reversal agents. The com