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pro vyhledávání: '"59"'
Autor:
William R. Wilson, Robert F. Anderson, Dianne M. Ferry, Nuala A. Helsby, Alison Hogg, Shangjin Yang, Brian D. Palmer, Graham J. Atwell, William A. Denny, Susan M. Pullen
Publikováno v:
Journal of Medicinal Chemistry. 47:3295-3307
The 5-aziridinyl-2,4-dinitrobenzamide CB 1954 is a substrate for the oxygen-insensitive nitroreductase (NTR) from E. coli and is in clinical trial in combination with NTR-armed adenoviral vectors in a GDEPT protocol; CB 1954 is also of interest for s
Autor:
Madeleine Blanc, Luc Choisnard, Denis Wouessidjewe, Edwige Nicolle, Pierre-Alain Carrupt, Annabelle Gèze, Eva-Laure Matera, Ahcène Boumendjel, Charles Dumontet, Julien Boccard
Publikováno v:
Journal of Medicinal Chemistry, Vol. 51, No 7 (2008) pp. 2307-10
A series of 59 chalcones was prepared and evaluated for the antimitotic effect against K562 leukemia cells. The most active chalcones were evaluated for their antiproliferative activity against a panel of 11 human and murine cell cancer lines. We fou