Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Smith, David A."'
Autor:
Stephen G. Taylor, Jonathan R.S. Arch, Smith David Glynn, Derek R. Buckle, Ashley E. Fenwick, Ivan Leo Pinto, Catherine S. V. Houge-Frydrych, John M. Tedder
Publikováno v:
Journal of Medicinal Chemistry. 33:3028-3034
A series of 4-amido-3,4-dihydro-2H-1-benzopyran-3-ols and 4-amido-2H-1-benzopyrans related to the potassium channel activator cromakalim have been prepared and evaluated for their relaxant activity in guinea pig isolated tracheal spirals. Several ana
Autor:
Ashley E. Fenwick, Mark S. Smallridge, Kenneth J. Murray, Brendan J. Connolly, Simon A. Readshaw, Jonathan R.S. Arch, Derek R. Buckle, Smith David Glynn, Keith Foster
Publikováno v:
Journal of medicinal chemistry. 37(4)
Alkylation of the selective type IV phosphodiesterase inhibitor, 8-amino-1,3-bis(cyclopropylmethyl)-xanthine (1, BRL 61063), led exclusively to the N-7 substituted derivatives 2-9, which showed varying selectivities for the PDE type IV isoenzyme rela
Autor:
Smith David Glynn, Claire Carey, Hilary Parr-Dobrzanski, Stephen G. Taylor, Ivan Leo Pinto, Andrew Faller, Catherine S. V. Houge-Frydrych, Derek R. Buckle, Jonathan R.S. Arch, Keith Foster
Publikováno v:
Journal of medicinal chemistry. 34(8)
Structural modifications of the potassium channel activator cromakalim (1) are described in which the amide moiety at C-4 has been replaced by carboxamide and thiocarboxamide functions. Analogues in which the hydroxyl group at C-3 has been oxidized o