Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Vincent C"'
Publikováno v:
Journal of Medical Virology. 74:573-579
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that infects a variety of cell types in vivo. A region (referred to as UL/b') present in the Toledo strain of HCMV and low passage clinical isolates contains 22 additional genes, which are absent
Autor:
Vincent C. Emery, Esteban Herrero-Martinez, Christine A. Lee, Deenan Pillay, Ian M. Jones, Caroline A. Sabin
Publikováno v:
Journal of Medical Virology. 72:187-193
The effect of highly active antiretroviral therapy (HAART) on HCV replication is controversial, with some studies reporting no effect and others increases, reductions and even clearances of HCV RNA after treatment. In this study, the effect of HAART
Autor:
Vincent C. Emery, Debra C. Quenelle, Paul D. Griffiths, Nigel J. Temperton, Keirissa M. Lawson, Jane N. Zuckerman, Earl R. Kern
Publikováno v:
Journal of Medical Virology. 70:86-90
A human cytomegalovirus (HCMV) glycoprotein B (gpUL55) DNA vaccine has been evaluated in BALB/c mice. Intramuscular immunization of these mice with pRc/CMV2-gB resulted in the generation of high levels of gpUL55-specific antibody (geometric mean tite
Publikováno v:
Journal of Medical Virology. 64:283-289
The quantity of human cytomegalovirus (HCMV) DNA in the blood of immunocompromised individuals correlates with the development of HCMV disease. We wished to determine which leukocytes harboured DNA and whether this represented active viral replicatio
Autor:
Vincent C. Emery, Keith Rolles, Ak Burroughs, Mounir Ait-Khaled, Andrew N. Phillips, Paul D. Griffiths, CP Bearcroft, Alberto Quaglia, S N Knight, S M Noibi, D A Clark, S E Davies, Kidd Im, A. V. Cope
Publikováno v:
Journal of Medical Virology. 59:496-501
Because cytomegalovirus (CMV) is an important opportunistic infection after liver transplant, we conducted a prospective study to see if the same applied to human herpesviruses (HHV)-6 and -7. We used polymerase chain reaction (PCR) methods optimised
Autor:
P Wilson, E.F. Bowen, Margaret A. Johnson, M. Grzywacz, Vincent C. Emery, Jane R. Deayton, Paul D. Griffiths
Publikováno v:
Journal of Medical Virology. 59:323-328
Reactivation of cytomegalovirus (CMV) following immunosuppression may result in the development of CMV disease and is associated with an increased risk of death. CMV viraemia detected by the polymerase chain reaction (PCR) precedes CMV disease in HIV
Autor:
Paul D. Griffiths, Margaret A. Johnson, E.F. Bowen, J.M. Cherrington, Vincent C. Emery, P.D. Lamy
Publikováno v:
Journal of Medical Virology. 58:402-407
Five AIDS patients with cytomegalovirus (CMV) retinitis who had received ganciclovir (GCV) therapy were followed with serial blood sampling to detectchanges both in CMV load and in the genetic composition of genes UL97 and UL54 whilst receiving cidof
Autor:
P. Sweny, Caroline A. Sabin, Paul D. Griffiths, Vincent C. Emery, Aycan F. Hassan-Walker, Kidd Im
Publikováno v:
Journal of Medical Virology. 58:182-187
A prospective longitudinal study of 87 renal allograft recipients identified 31 patients with cytomegalovirus (CMV) viraemia. Previous studies have identified CMV viraemia, donor positivity, and CMV load in urine as independent risk factors for disea
Autor:
Paul D. Griffiths, Margaret Johnson, A N Phillips, D A Clark, M Atkins, Kidd Im, James E. McLaughlin, Bowen Ef, Padraig Strappe, Vincent C. Emery
Publikováno v:
Journal of Medical Virology. 57:278-282
In vitro, β-herpesviruses can stimulate or inhibit HIV replication under particular circumstances. In order to investigate the effects of β-herpesvirus infection on HIV replication and vice versa at an organ level, we determined the quantitative re
Autor:
Margaret Johnson, Padraig Strappe, Paul D. Griffiths, Steve Kaye, Clive Loveday, James E. McLaughlin, Vincent C. Emery, Richard S. Tedder, Mark Atkins
Publikováno v:
Journal of Medical Virology. 55:138-146
Replication of HIV introduces errors into the genome which are responsible for conferring a growth advantage over wildtype virus when drugs such as zidovudine (ZDV) exert a selective pressure. The molecular basis for HIV-1 resistance to ZDV has been