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Publikováno v:
Journal of Medical Virology. 93:4975-4981
The use of direct-acting antiviral agents (DAAs) in patients with chronic HCV genotype (GT) 1 infection results in sustained virologic response (SVR) rates of 95%-97%, but 3%-5% of patients experience virologic failure. We observed 41 patients infect
Autor:
Roberto Guevara, Michelle A Davis, Felix Emeka Anyiam, Monique G. Davis, Suresh Antony, Nouf K Almaghlouth
Publikováno v:
Journal of Medical Virology
Background Recent literature suggests that approximately 5‐18% of patients diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) may progress rapidly to a severe form of the illness and subsequent death. We examined the re
Autor:
Meng-Lan Wang, Dong-Bo Wu, En-Qiang Chen, Hong Tang, Dong-Mei Zhang, Juan Liao, Ya-Chao Tao, Yong-Hong Wang
Publikováno v:
Journal of Medical Virology. 92:302-308
Aims The aim of this retrospective study was to compare the efficacy and safety of tenofovir disoproxil fumarate (TDF) monotherapy and TDF + entecavir (ETV) combination therapy for chronic hepatitis B (CHB) patients with the partial virological respo
Publikováno v:
Journal of Medical Virology. 91:2166-2173
Background Persistence of hepatitis C virus (HCV) infection and response to antiviral therapy has been shown to be associated with inappropriate levels of cytokines and microRNAs (miRNAs). miRNA levels have been reported to fluctuate during treatment
Autor:
Stephen T. Barclay, M. Priest, Sumita Verma, G. Abouda, Andrew Fraser, Brendan Healy, Lucia Macken, William Gelson, William L. Irving
Publikováno v:
Journal of Medical Virology. 91:1979-1988
Direct‐acting antivirals (DAAs) have revolutionised the management of chronic hepatitis C virus (HCV) infection. We describe UK real‐world DAA experience. Individuals commencing HCV treatment containing a DAA regimen (Mar 2014‐Nov 2016), partic
Publikováno v:
Journal of Medical Virology. 92:1253-1259
The risk of herpes zoster (HZ) increases with age and declining immune function. Increased oxidative stress and inflammatory conditions may cause a negative impact on the immune responses. The present study aimed to assess the levels of oxidative/inf
Autor:
Mohammed Abd Algaber, Heba Omar, Yasmeen Abd El Latif, Mohamed El Kassas, Kadry Elsaeed, Magdy El-Serafy, Wahid Doss, Hesham El Halwagy, Shimaa Afify, Adel El Tahan, Mohamed Alboraie
Publikováno v:
Journal of Medical Virology. 94:667-674
INTRODUCTION AND AIMS Treatment of hepatitis C virus (HCV) genotype 4 patient with fixed dose combination of ombitasvir-paritaprevir-ritonavir plus ribavirin (OBV/rPTV/RBV) has been proven efficacy and safety in many clinical trials. The current stud
Autor:
Rui Huang, Deyuan Jiang, Qing Xie, Zhiliang Gao, Wu Li, Lai Wei, Benedetta Massetto, Luisa M. Stamm, Hongmei Mo, Huiying Rao, Diana M. Brainard
Publikováno v:
Journal of Medical Virology. 91:1313-1318
Background and aim Genotype 3b hepatitis C virus (HCV) infection represents approximately 50% of patients with genotype 3 in China. We compared the efficacy of sofosbuvir (SOF) plus ribavirin (RBV) in Chinese patients with genotype 3a and 3b HCV. Met
Autor:
Jeong Won Jang, Si Hyun Bae, Myeong Jun Song, Seung Kew Yoon, Seok Hwan Kim, Sang Wook Choi, Nam Ik Han, Pil Soo Sung, Do Seon Song, Sun Hong Yoo, Se Hyun Cho, Jin Mo Yang, Sung Won Lee, Soon Woo Nam, Hae Lim Lee, Joon-Yeol Han, Jung Hyun Kwon, Jong Young Choi, Hee Yeon Kim, Chan Ran You, Chang Wook Kim, U Im Chang
Publikováno v:
Journal of Medical Virology. 91:1104-1111
Background A real-life study is essential outside clinical trials. The aim is to evaluate the clinical outcomes of direct acting agents (DAA) for patients with chronic hepatitis C (CHC) in real practice. Methods We analyzed 590 consecutively enrolled
Autor:
Heba Omar, Mahmoud Abdo, Abdallah Qawzae, Mohamed Abdel-Samiee, Ahmed Moustafa, Essam A. Hassan, Gamal Esmat, Tamer Elbaz, Mostafa G. Gamil, Amr Mohamed Zaghloul
Publikováno v:
Journal of Medical Virology. 91:272-277
Hepatitis C virus (HCV) infection is considered as a major public health problem that, worldwide, chronically affects 170 million people. Elderly patients are more likely than younger patients to have increased duration of infection, increased rate o