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Autor:
Changning Li, Puja Panwar Hazari, Abhishek Kumar, Supriya D. Mahajan, Ravikumar Aalinkeel, Anu Sharma, Mark T. Swihart, Rakesh Kumar Sharma
Publikováno v:
Journal of Materials Chemistry B. 9:2505-2514
Cannabidiol (CBD) has been shown to slow cancer cell growth and is toxic to human glioblastoma cell lines. Thus, CBD could be an effective therapeutic for glioblastoma. In the present study, we explored the anticancer effect of cannabidiol loaded mag
Autor:
Xugang Dang, Feng Xu, Guoliang Li, Jingwen Xu, Xin Ge, Yan Yang, Mingzhen Zhang, Xiangji Yan, Yan-Ling Luo
Publikováno v:
Journal of Materials Chemistry B. 9:1297-1314
The efficacy of ongoing anticancer treatment is often compromised by some barriers, such as low drug content, nonspecific release of drug delivery system, and multidrug resistance (MDR) effect of tumors. Herein, in the research a novel functionalized
Autor:
Haiyan Xu, Fangzhou Liu, Yu Zhang, Haijiao Dong, Fei Kong, Huiyuan Bai, Quanhao Sun, Ming Ma, Chen Wang, Ning Gu
Publikováno v:
Journal of Materials Chemistry B. 9:5245-5254
Multifunctional drug delivery systems combining two or more therapies have a wide-range of potential for high efficacy tumor treatment. Herein, we designed a novel hollow mesoporous Prussian blue nanoparticles (HMPBs)-based platform for targeted and
Autor:
Tianyou Chen, Qiuting Li, Han Hu, Zhe Yang, Zizhen Qin, Qi Xu, Zhimin Mo, Zushun Xu, Piao Huang, Shengli Yang
Publikováno v:
Journal of Materials Chemistry B. 9:9908-9922
Lenvatinib (LT) is gradually replacing sorafenib as an alternative targeted drug against advanced hepatocellular carcinoma (HCC). However, the anticancer effects of LT are still limited because of its low cytotoxicity, multidrug resistance (MDR), and
Publikováno v:
Journal of Materials Chemistry B. 9:864-875
The increase in drug-resistant strains of Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), has led to an increased rate of infection-related mortality. The emergence of drug resistance has rendered many antibiotics ineffectiv
Publikováno v:
Journal of Materials Chemistry B. 9:187-194
In this study, an enhanced anticancer strategy combining the chemotherapy from antineoplastics with the oxidative damage from a sulfur dioxide (SO2) prodrug is presented. Based on the characteristics of a high glutathione (GSH) level in the tumor mic
Autor:
Rui Zhou, Jiatao Yang, Yucheng Xiang, Yuan Huang, Qiuyi Li, Minglu Zhou, Dandan Xie, Xi Lin, Zhou Zhou
Publikováno v:
Journal of Materials Chemistry B. 9:1336-1350
Distant organ metastasis is the main cause of death in breast cancer patients. Evidences have shown that mitochondria also play a crucial role in tumor metastasis, except for as apoptosis center. However, the treatment of tumor growth and metastasis
Publikováno v:
Journal of Materials Chemistry B. 9:8626-8630
ATP acts as a biological hydrotrope preventing protein aggregation. Here, we report a novel chimeric peptide, ACC1-13K8, with an unusual capacity to bind and incorporate ATP while self-assembling into amyloid fibrils. The amino acid sequence combines
Autor:
Mengyuan Liu, Jingyi An, Shizhen Geng, Xiang Lu, Ge Zhang, Lulu Sun, Zhenzhong Zhang, Hongling Zhang, Shudong Zhang, Binghua Wang
Publikováno v:
Journal of Materials Chemistry B. 9:147-158
Pore-forming toxins (PFTs), the most common virulence proteins, are promising therapeutic keys in bacterial infections. CAL02, consisting of sphingomyelin (Sm) and containing a maximum ratio of cholesterol (Ch), has been applied to sequester PFTs. Ho
Publikováno v:
Journal of Materials Chemistry B. 9:1988-2000
Chemo/chemodynamic synergistic therapy is a promising strategy to improve the antitumor effect. However, hypoxia and a limited amount of hydrogen peroxide (H2O2) in the tumor microenvironment (TME) severely restrict the therapeutic efficacy of this c