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Autor:
Jos Jonkers, Patrick W. B. Derksen
Publikováno v:
Journal of Mammary Gland Biology and Neoplasia. 12(2-3):191-203
Metastatic disease is the major cause of death in breast cancer patients. Patients presenting with metastases cannot be cured, and as a consequence, treatment is palliative and focuses on prolonging survival and maintaining quality of life. Numerous
Publikováno v:
Journal of Mammary Gland Biology and Neoplasia
Understanding the complex events leading to formation of an epithelial-based organ such as the breast requires a detailed insight into the crosstalk between epithelial and stromal compartments. These interactions occur both through heterotypic cellul
Autor:
Richard Barrett-Jolley, Ali Mobasheri
Publikováno v:
Journal of Mammary Gland Biology and Neoplasia
Aquaporins are membrane proteins that play fundamental roles in water and small solute transport across epithelial and endothelial barriers. Recent studies suggest that several aquaporin proteins are present in the mammary gland. Immunohistochemical
Autor:
Leif R. Lund, Kirsty A. Green, Boye Schnack Nielsen, Anna Juncker-Jensen, John Rømer, Kasper Almholt
Publikováno v:
Journal of Mammary Gland Biology and Neoplasia
Growth and invasion of breast cancer require extracellular proteolysis in order to physically restructure the tissue microenvironment of the mammary gland. This pathological tissue remodeling process depends on a collaboration of epithelial and strom
Publikováno v:
Journal of Mammary Gland Biology and Neoplasia
Most mammals develop their mammary glands in pairs of which the two counterparts are symmetrically displaced away from the ventral midline. Based on this symmetry and the same functional outcome as a milk-producing organ, the mammary glands are easil