Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Elias, P."'
Autor:
Wei Liu, Libin Xu, Connor R. Lamberson, Louise S. Merkens, Robert D. Steiner, Ellen R. Elias, Dorothea Haas, Ned A. Porter
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 1, Pp 244-253 (2013)
Smith-Lemli-Opitz syndrome (SLOS) is caused by mutations in the gene encoding 3β-hydroxysterol-Δ7-reductase and as a result of this defect, 7-dehydrocholesterol (7-DHC) and 8-dehydrocholesterol (8-DHC) accumulate in the fluids and tissues of patien
Externí odkaz:
https://doaj.org/article/c09b05fab6df45d5b9a9957e60245662
Autor:
Biao Lu, Yan J. Jiang, Peggy Kim, Art Moser, Peter M. Elias, Carl Grunfeld, Kenneth R. Feingold
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 11, Pp 3207-3216 (2010)
Phospholipids are required for epidermal lamellar body formation. Glycerol 3-phosphate acyltransferases (GPATs) catalyze the initial step in the biosynthesis of glycerolipids. Little is known about the expression and regulation of GPATs in epidermis/
Externí odkaz:
https://doaj.org/article/34b27d7475e24a42a8d34b36b0dd2f0e
Autor:
Yan J. Jiang, Biao Lu, Elizabeth J. Tarling, Peggy Kim, M-Q. Man, Debbie Crumrine, Peter A. Edwards, Peter M. Elias, Kenneth R. Feingold
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 11, Pp 3185-3195 (2010)
ABCG1, a member of the ATP binding cassette superfamily, facilitates the efflux of cholesterol from cells to HDL. In this study, we demonstrate that ABCG1 is expressed in cultured human keratinocytes and murine epidermis, and induced during keratinoc
Externí odkaz:
https://doaj.org/article/1048b00c62c74a7a8d6c99108b07fd5a
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 8, Pp 1677-1681 (2008)
Glycosphingolipids (GSLs) have been implicated as potential atherogenic lipids. Studies in apolipoprotein E-null (apoE−/−) mice indicate that exacerbated tissue GSL accumulation resulting from α-galactosidase deficiency promotes atherosclerosis,
Externí odkaz:
https://doaj.org/article/d8f8969a879c40109a1e7508fe6527b8
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 5, Pp 1068-1076 (2008)
The methionine choline-deficient (MCD) diet results in liver injury similar to human nonalcoholic steatohepatitis (NASH). The aims of this study were to define mechanisms of MCD-induced steatosis in insulin-resistant db/db and insulin-sensitive db/m
Externí odkaz:
https://doaj.org/article/6e3f8c92834e49d0994a74d99d4549bd
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 4, Pp 697-714 (2008)
Many of the ichthyoses are associated with inherited disorders of lipid metabolism. These disorders have provided unique models to dissect physiologic processes in normal epidermis and the pathophysiology of more common scaling conditions. In most of
Externí odkaz:
https://doaj.org/article/cfa65d6843bf40e0949cdbee67e22aa7
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 3, Pp 499-509 (2008)
The epidermis is a very active site of lipid metabolism, and all peroxisome proliferator-activated receptor (PPAR) and liver X receptor (LXR) isoforms are expressed in the epidermis. Activation of PPARα, -β/δ, or -γ or LXRs stimulates keratinocyt
Externí odkaz:
https://doaj.org/article/3ed690eed214475cb15dd346729bcca2
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 2, Pp 324-331 (2008)
The serine palmitoyl transferase inhibitor myriocin potently suppresses the development of atherosclerosis in apolipoprotein E (apoE) gene knockout (apoE−/−) mice fed a high-fat diet. This is associated with reduced plasma sphingomyelin (SM) and
Externí odkaz:
https://doaj.org/article/09a3d02ea6314eb9a104de9b2f8d1ac6
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 10, Pp 2248-2258 (2006)
Keratinocytes require abundant cholesterol for cutaneous permeability barrier function; hence, the regulation of cholesterol homeostasis is of great importance. ABCA1 is a membrane transporter responsible for cholesterol efflux and plays a pivotal ro
Externí odkaz:
https://doaj.org/article/33a47b2967da4a5c956ac0e22fcbbeda
Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis
Autor:
Evi Houben, Walter M. Holleran, Toshiaki Yaginuma, Cungui Mao, Lina M. Obeid, Vera Rogiers, Yutaka Takagi, Peter M. Elias, Yoshikazu Uchida
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 5, Pp 1063-1070 (2006)
Ceramides (Cers) accumulate within the interstices of the outermost epidermal layers, or stratum corneum (SC), where they represent critical components of the epidermal permeability barrier. Although the SC contains substantial sphingol, indicative o
Externí odkaz:
https://doaj.org/article/066e53dc1f434628a473ca7c161d326f