Zobrazeno 1 - 8
of 8
pro vyhledávání: '"59"'
Autor:
Jean Buteau, Jelske N. van der Veen, Rick Havinga, Folkert Kuipers, Randal Nelson, Kelly-Ann Leonard, John P. Kennelly, René L. Jacobs
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1695-1708 (2018)
Journal of Lipid Research, 59(9), 1695-1708. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Journal of Lipid Research, 59(9), 1695-1708. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-alpha (CT alpha) is required for VLDL secretion. To determine the precise role of de novo PC synthesis in intestinal lipid metabolism, we deleted CT alpha exclusiv
Autor:
Neale D. Ridgway, Jonghwa Lee
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 1940-1950 (2018)
Intracellular lipid droplets (LDs) supply fatty acids for energy, membrane biogenesis, and lipoprotein secretion. The surface monolayer of LDs is composed of phospholipids, primarily phosphatidylcholine (PC), that stabilize the neutral lipid core of
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 59, Iss 9, Pp 1685-1694 (2018)
Journal of Lipid Research, Vol 59, Iss 9, Pp 1685-1694 (2018)
It is a challenge to assess metabolic dysregulation in fatty liver of human patients prior to clinical manifestations. Here, we recruited obese, but otherwise healthy, subjects to examine biochemical processes in the liver with simple triglyceride ac
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 3, Pp 404-415 (2018)
SID1 transmembrane family member 2 (Sidt2) is an integral lysosomal membrane protein. To investigate its explicit function, we generated a global Sidt2 knockout mouse model (Sidt2(−/−)). Compared with the littermate controls, Sidt2(−/−) mice
Autor:
Curtis J. Bare, Michele Alves-Bezerra, Anal Desai, Yue Li, Yingxia Li, David E. Cohen, Susan J. Hagen, Cafer Ozdemir
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 2, Pp 368-379 (2018)
Thioesterase superfamily member 1 (Them1) is an acyl-CoA thioesterase that is highly expressed in brown adipose tissue, where it functions to suppress energy expenditure. Lower Them1 expression levels in the liver are upregulated in response to high-
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 5, Pp 820-829 (2018)
Department of Food Science Faculty Publications
Department of Food Science Faculty Publications
As adipose tissue is the major cholesterol storage organ and most of the intracellular cholesterol is distributed to lipid droplets (LDs), cholesterol homeostasis may have a role in the regulation of adipocyte size and function. ACATs catalyze the fo
Regulation of mitochondrial trifunctional protein modulates nonalcoholic fatty liver disease in mice
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 6, Pp 967-973 (2018)
Journal of Lipid Research
Journal of Lipid Research
Mitochondrial trifunctional protein (MTP) plays a critical role in the oxidation of long-chain fatty acids. We previously reported that aging mice (>9 months old) heterozygous for an MTP defect (MTP+/−) develop nonalcoholic fatty liver disease (NAF
Autor:
Patrick Couture, Jean-Philippe Drouin-Chartier, Jean-Charles Hogue, Benoît Lamarche, Valéry Lemelin, André J. Tremblay
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 8, Pp 1501-1509 (2018)
Intestinal triglyceride (TG)-rich lipoproteins (TRLs) are important in the pathogenesis of atherosclerosis in insulin resistance (IR). We investigated the association of plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations with