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Autor:
Jean Buteau, Jelske N. van der Veen, Rick Havinga, Folkert Kuipers, Randal Nelson, Kelly-Ann Leonard, John P. Kennelly, René L. Jacobs
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1695-1708 (2018)
Journal of Lipid Research, 59(9), 1695-1708. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Journal of Lipid Research, 59(9), 1695-1708. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-alpha (CT alpha) is required for VLDL secretion. To determine the precise role of de novo PC synthesis in intestinal lipid metabolism, we deleted CT alpha exclusiv
Autor:
Neale D. Ridgway, Jonghwa Lee
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 1940-1950 (2018)
Intracellular lipid droplets (LDs) supply fatty acids for energy, membrane biogenesis, and lipoprotein secretion. The surface monolayer of LDs is composed of phospholipids, primarily phosphatidylcholine (PC), that stabilize the neutral lipid core of