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Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1685-1694 (2018)
It is a challenge to assess metabolic dysregulation in fatty liver of human patients prior to clinical manifestations. Here, we recruited obese, but otherwise healthy, subjects to examine biochemical processes in the liver with simple triglyceride ac
Externí odkaz:
https://doaj.org/article/9118e872584e43d796c87543bd99b66c
Autor:
Anal Desai, Michele Alves-Bezerra, Yingxia Li, Cafer Ozdemir, Curtis J. Bare, Yue Li, Susan J. Hagen, David E. Cohen
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 2, Pp 368-379 (2018)
Thioesterase superfamily member 1 (Them1) is an acyl-CoA thioesterase that is highly expressed in brown adipose tissue, where it functions to suppress energy expenditure. Lower Them1 expression levels in the liver are upregulated in response to high-
Externí odkaz:
https://doaj.org/article/b052521a498d4dce9a173b3804feb67c
Akademický článek
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Autor:
Curtis J. Bare, Michele Alves-Bezerra, Anal Desai, Yue Li, Yingxia Li, David E. Cohen, Susan J. Hagen, Cafer Ozdemir
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 2, Pp 368-379 (2018)
Thioesterase superfamily member 1 (Them1) is an acyl-CoA thioesterase that is highly expressed in brown adipose tissue, where it functions to suppress energy expenditure. Lower Them1 expression levels in the liver are upregulated in response to high-
Regulation of mitochondrial trifunctional protein modulates nonalcoholic fatty liver disease in mice
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 6, Pp 967-973 (2018)
Journal of Lipid Research
Journal of Lipid Research
Mitochondrial trifunctional protein (MTP) plays a critical role in the oxidation of long-chain fatty acids. We previously reported that aging mice (>9 months old) heterozygous for an MTP defect (MTP+/−) develop nonalcoholic fatty liver disease (NAF