Zobrazeno 1 - 7
of 7
pro vyhledávání: '"59"'
Autor:
Guolin Li, Kristopher W. Krausz, Chad Brocker, Jiang Yue, Frank J. Gonzalez, Donghwan Kim, Tingting Yan, Thomas J. Velenosi, Daxesh P. Patel
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 11, Pp 2140-2152 (2018)
PPARα (PPARA), expressed in most oxidative tissues, is a major regulator of lipid homeostasis; hepatic PPARA plays a critical role during the adaptive fasting response by promoting FA oxidation (FAO). To clarify whether extrahepatic PPARA activity c
Autor:
Susan E. Appt, Eric M. Morrel, Geeta Datta, David W. Garber, Dennis I. Goldberg, Mayakonda N. Palgunachari, C. Roger White, Gattadahalli M. Anantharamaiah, Thomas C. Register
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 11, Pp 2075-2083 (2018)
Journal of Lipid Research
Journal of Lipid Research
Ac-hE18A-NH2 is a dual-domain apoE mimetic peptide that possesses the putative receptor binding domain from apoE (LRKLRKRLLR, denoted hE; residues 141–150) covalently attached to lipid-associating peptide 18A. Like apoE, Ac-hE18A-NH2 reduces plasma
Autor:
Shizhong Zheng, Elizabeth P. Newberry, Alan D. Attie, David A. Bernlohr, William S. Blaner, Jianguo Lin, Nicholas O. Davidson, Anping Chen, Mark P. Keller
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 3, Pp 416-428 (2018)
Hepatic stellate cell (HSC) activation occurs along with decreased Perilipin5 (Plin5) and liver fatty acid-binding protein (L-Fabp) expression and coincident lipid droplet (LD) depletion. Conversely, the activated phenotype is reversible in WT HSCs u
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 3, Pp 404-415 (2018)
SID1 transmembrane family member 2 (Sidt2) is an integral lysosomal membrane protein. To investigate its explicit function, we generated a global Sidt2 knockout mouse model (Sidt2(−/−)). Compared with the littermate controls, Sidt2(−/−) mice
Autor:
George Michailidis, Lucy M. Hinder, Eva L. Feldman, Viji Nair, Frank C. Brosius, Thomas W. Gardner, Kelli M. Sas, H. V. Jagadish, Tanu Soni, Matthias Kretzler, Steven F. Abcouwer, Thekkelnaycke M. Rajendiran, Jiahe Lin, Subramaniam Pennathur
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 2, Pp 173-183 (2018)
Lipids are ubiquitous metabolites with diverse functions; abnormalities in lipid metabolism appear to be related to complications from multiple diseases, including type 2 diabetes. Through technological advances, the entire lipidome has been characte
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 7, Pp 1276-1282 (2018)
Metabolic flexibility, the capacity to adapt to fuel availability for energy production, is crucial for maintaining whole-body energy homeostasis. An inability to adequately promote FA utilization is associated with lipid accumulation in peripheral t
Autor:
Kaushala S. Jayawardana, Jan Greve, Kevin Huynh, Matthew J. Watt, Sander S. Rensen, Peter J. Meikle, Ruth C. R. Meex, Kang-Yu Peng
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 1977-1986 (2018)
Journal of Lipid Research
Journal of Lipid Research, 59(10), 1977-1986. American Society for Biochemistry and Molecular Biology, Inc.
Journal of Lipid Research
Journal of Lipid Research, 59(10), 1977-1986. American Society for Biochemistry and Molecular Biology, Inc.
Nonalcoholic fatty liver disease (NAFLD) comprises fat-accumulating conditions within hepatocytes that can cause severe liver damage and metabolic comorbidities. Studies suggest that mitochondrial dysfunction contributes to its development and progre