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pro vyhledávání: '"59"'
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 12, Pp 2383-2396 (2018)
Journal of Lipid Research
Journal of Lipid Research
PUFAs are important constituents of membrane glycerophospholipids. However, changes in the capacities to incorporate and metabolize PUFAs when cells enter the cell cycle have not been thoroughly studied. In this study, differences in the incorporatio
Autor:
Ellis M. Pearson, Ming Jing Wu, Aspen R. Gutgsell, Alan T. Remaley, Anna Wolska, Saskia B. Neher, Benjamin S. Roberts
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 12, Pp 2456-2465 (2018)
LPL is a secreted enzyme that hydrolyzes triglycerides from circulating lipoproteins. Individuals lacking LPL suffer from severe hypertriglyceridemia, a risk factor for acute pancreatitis. One potential treatment is to administer recombinant LPL as a
NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains
Autor:
Yuta Odagiri, Yui Kikuchi, Wataru Nihei, Yumi Tamura, Hirotaka Hayamizu, Masakazu Nagafuku, Jin-ichi Inokuchi, Kazuya Kabayama, Hirotaka Kanoh, Kenta Arai, Kei-ichiro Inamori, Koichi Fukase, Lucas Veillon
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 11, Pp 2181-2187 (2018)
Intestinal cholesterol absorption is a key regulator of systemic cholesterol homeostasis. Excessive dietary cholesterol and its intestinal uptake lead to hypercholesterolemia, a major risk factor for cardiovascular disease. Intestinal cholesterol upt
Autor:
Guolin Li, Kristopher W. Krausz, Chad Brocker, Jiang Yue, Frank J. Gonzalez, Donghwan Kim, Tingting Yan, Thomas J. Velenosi, Daxesh P. Patel
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 11, Pp 2140-2152 (2018)
PPARα (PPARA), expressed in most oxidative tissues, is a major regulator of lipid homeostasis; hepatic PPARA plays a critical role during the adaptive fasting response by promoting FA oxidation (FAO). To clarify whether extrahepatic PPARA activity c
Autor:
Susan E. Appt, Eric M. Morrel, Geeta Datta, David W. Garber, Dennis I. Goldberg, Mayakonda N. Palgunachari, C. Roger White, Gattadahalli M. Anantharamaiah, Thomas C. Register
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 11, Pp 2075-2083 (2018)
Journal of Lipid Research
Journal of Lipid Research
Ac-hE18A-NH2 is a dual-domain apoE mimetic peptide that possesses the putative receptor binding domain from apoE (LRKLRKRLLR, denoted hE; residues 141–150) covalently attached to lipid-associating peptide 18A. Like apoE, Ac-hE18A-NH2 reduces plasma
Autor:
Andrew J. Lutkewitte, Michael P Franczyk, Samuel Klein, Angela M. Hall, Terri A. Pietka, Brian N. Finck, Kim H.H. Liss, Jun Yoshino
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 59, Iss 9, Pp 1630-1639 (2018)
Journal of Lipid Research, Vol 59, Iss 9, Pp 1630-1639 (2018)
Adipocyte triglyceride storage provides a reservoir of energy that allows the organism to survive times of nutrient scarcity, but excessive adiposity has emerged as a health problem in many areas of the world. Monoacylglycerol acyltransferase (MGAT)
Autor:
Zhen Liu, Bernard Zinman, Stewart B. Harris, Richard P. Bazinet, Adria Giacca, Luke W. Johnston, Anthony J. Hanley, Ravi Retnakaran
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1751-1762 (2018)
AimsOur aim was to examine longitudinal associations of triacylglyceride fatty acid (TGFA) composition with insulin sensitivity (IS) and beta-cell function.MethodsAdults at-risk for T2D (n=477) had glucose and insulin measured from a glucose challeng
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 3, Pp 404-415 (2018)
SID1 transmembrane family member 2 (Sidt2) is an integral lysosomal membrane protein. To investigate its explicit function, we generated a global Sidt2 knockout mouse model (Sidt2(−/−)). Compared with the littermate controls, Sidt2(−/−) mice
Autor:
Kathryn E. Hopperton, R.J. Scott Lacombe, Adam H. Metherel, Rapha eumll Chouinard-Watkins, Richard P. Bazinet
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 2, Pp 357-367 (2018)
Previous assessments of the PUFA biosynthesis pathway have focused on DHA and arachidonic acid synthesis. Here, we determined whole-body synthesis-secretion kinetics for all downstream products of PUFA metabolism, including direct measurements of DHA
Publikováno v:
Journal of Lipid Research, Vol 33, Iss 10, Pp 1493-1501 (1992)
Serum lipoprotein[a] (Lp[a]) is a strong risk factor for coronary heart disease. We therefore examined the effect of dietary fatty acid composition on serum Lp[a] levels in three strictly controlled experiments with healthy normocholesterolemic men a