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Autor:
Gregory C. Shearer, Anne Marie Chang, Margeaux M Schade, Kelly M Ness, Orfeu M. Buxton, Nicole G. Nahmod, Stephen M. Strayer
Publikováno v:
J Lipid Res
Journal of Lipid Research, Vol 60, Iss 11, Pp 1935-1945 (2019)
Journal of Lipid Research, Vol 60, Iss 11, Pp 1935-1945 (2019)
Chronic sleep restriction, or inadequate sleep, is associated with increased risk of cardiometabolic disease. Laboratory studies demonstrate that sleep restriction causes impaired whole-body insulin sensitivity and glucose disposal. Evidence suggests
Autor:
Michael D. Jensen, Yilin Song
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100131-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100131-(2021)
Most research into red blood cell (RBC) lipids focuses on membrane phospholipids and their relationships to metabolic conditions and diet. Triglycerides (TGs) exist in most cells; the TG-fatty acids serve as readily available fuel for oxidative phosp
Autor:
Kylie J. Schache, Kelli L. Sylvers-Davie, Ashley Segura-Roman, Brandon S.J. Davies, Alicia M. Salvi
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100112-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100112-(2021)
High plasma triglyceride (TG) levels and low HDL-C levels are risk factors for atherosclerosis and cardiovascular disease. Both plasma TG and HDL-C levels are regulated in part by the circulating inhibitor, angiopoietin-like 3 (ANGPTL3). ANGPTL3 inhi
Autor:
Chris Boesch, Katie Carr, Leanne Hodson, Alison Sleigh, Graham J. Kemp, Krishna K Chatterjee, David B. Savage, Claire Adams, Laura Watson, Soren Brage
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 60, Iss 7, Pp 1323-1332 (2019)
Journal of Lipid Research, Vol 60, Iss 7, Pp 1323-1332 (2019)
Intramyocellular lipid (IMCL) accumulation has been linked to both insulin-resistant and insulin-sensitive (athletes) states. Biochemical analysis of intramuscular triglyceride composition is confounded by extramyocellular triglycerides in biopsy sam
Autor:
Apostolos Taxiarchis, Rachel M. Fisher, Hovsep Mahdessian, Ferdinand M. van't Hooft, Angela Silveira
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 6, Pp 1069-1077 (2019)
J Lipid Res
J Lipid Res
Patatin-like phospholipase domain-containing proteins (PNPLAs) are involved in triglyceride hydrolysis and lipid-droplet homeostasis in mice, but the physiological significance of the PNPLAs for triglyceride metabolism in human hepatocytes is unclear
Autor:
Maria Camacho-Hughes, Zhanpin Wu, Robert R. Wolfe, Craig Porter, Labros S. Sidossis, Edgar L. Dillon, Elena Volpi, Rabia Asghar, Heidi Spratt, Clark R. Andersen, Nicola Abate, Maria Chondronikola, Demidmaa Tuvdendorj, Melinda Sheffield-Moore, William J. Durham
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 2018-2024 (2018)
Journal of lipid research, vol 59, iss 10
Journal of lipid research, vol 59, iss 10
Intramyocellular triglyceride (imTG) in skeletal muscle plays a significant role in metabolic health, and an infusion of [(13)C(16)]palmitate can be used to quantitate the in vivo fractional synthesis rate (FSR) and absolute synthesis rate (ASR) of i
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 59, Iss 9, Pp 1685-1694 (2018)
Journal of Lipid Research, Vol 59, Iss 9, Pp 1685-1694 (2018)
It is a challenge to assess metabolic dysregulation in fatty liver of human patients prior to clinical manifestations. Here, we recruited obese, but otherwise healthy, subjects to examine biochemical processes in the liver with simple triglyceride ac
Autor:
Frank M. van der Sande, Jochen G. Raimann, Alice Topping, Xiaoling Ye, Yuedong Wang, Bernard Canaud, Stefano Stuard, Len A. Usvyat, Peter Kotanko, Jeroen P. Kooman, George A. Kaysen
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, 59(8), 1519-1528. American Society for Biochemistry and Molecular Biology, Inc.
Journal of Lipid Research, 59(8), 1519-1528. American Society for Biochemistry and Molecular Biology, Inc.
Cardiovascular (CV) events are increased 36-fold in patients with end-stage renal disease. However, randomized controlled trials to lower LDL cholesterol (LDL-C) and serum total cholesterol (TC) have not shown significant mortality improvements. An i
Autor:
Michael A. Province, Hemant K. Tiwari, Bertha Hidalgo, Mary F. Feitosa, Degui Zhi, Paul N. Hopkins, Ingrid B. Borecki, Stella Aslibekyan, Robert J. Straka, Alexis C. Frazier-Wood, Marguerite R. Irvin, Xin Geng, Ping An, Kathleen A. Ryan, Braxton D. Mitchell, Jose M. Ordovas, Vinodh Srinivasasainagendra, Donna K. Arnett, Tushar Dave
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 4, Pp 722-729 (2018)
Our understanding of genetic influences on the response of lipids to specific interventions is limited. In this study, we sought to elucidate effects of rare genetic variants on lipid response to a high-fat meal challenge and fenofibrate (FFB) therap
Autor:
Jacqueline DeGraaf, Patrick Couture, Seth S. Martin, George Thanassoulis, Patrick R. Lawler, John T. Wilkins, William C. Cromwell, Allan D. Sniderman
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 7, Pp 1266-1275 (2018)
Triglycerides are the conventional tool to measure VLDLs, whereas LDL cholesterol (LDL-C) is the conventional tool to measure LDLs. Multiple epidemiological studies, including a series of genetically based analyses, have demonstrated that cardiovascu