Zobrazeno 81 - 90
of 228
pro vyhledávání: ''
Autor:
Serkalem Demissie, L. Adrienne Cupples, Philip A. Wolf, Roberto Elosua, Caroline S. Fox, Chao-Qiang Lai, Christopher J. O'Donnell, Ralph B. D'Agostino, Joseph F. Polak, Jose M. Ordovas
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 5, Pp 990-996 (2006)
Genetic variation at the apolipoprotein A5 gene (APOA5) is associated with increased triglyceride concentrations, a risk factor for atherosclerosis. Carotid intimal medial thickness (IMT) is a surrogate measure of atherosclerosis burden. We sought to
Autor:
Gérard Torpier, Hafid Mezdour, Jamila Fruchart, Jean Charles Fruchart, Graciela Castro, Maxime Nowak, G. Larigauderie, Mustapha Rouis, Nobuyo Maeda
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 5, Pp 912-920 (2006)
Human data raised the possibility that coronary heart disease is associated with mutations in the apolipoprotein gene cluster APOA1/C3/A4 that result in multideficiency of cluster-encoded apolipoproteins and hypoalphalipoproteinemia. To test this hyp
Autor:
Julia M. Keogh, Jian'an Luan, I. Sadaf Farooqi, Sarah Lowenbeim, John Edward Norris Morten, Stephen O'Rahilly, Sumit Bhattacharyya, Benjamin G. Challis, John Brennand, C. T. Montague, Nicholas J. Wareham, Suzanne Jenkins
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 4, Pp 761-766 (2006)
The gene encoding the melatonin-related receptor (GPR50) is highly expressed within hypothalamic nuclei concerned with the control of body weight and metabolism. We screened GPR50 for mutations in an obese cohort and identified an insertion of four a
Autor:
Lisa B. Bland, Tomasz M. Beer, Dianne Lemmon, Emily M. Wersinger, John D. Brunzell, Christopher W. Ryan, Jonathan Q. Purnell, Mark Garzotto
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 2, Pp 349-355 (2006)
Androgen deprivation therapy (ADT) for prostate cancer is now used in earlier disease stages and as adjuvant treatment. Recognizing and reducing the toxicity of this therapy, including worsened lipid levels and cardiovascular disease (CVD) risks, has
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 1, Pp 115-122 (2006)
Human plasma HDLs are classified on the basis of apolipoprotein composition into those that contain apolipoprotein A-I (apoA-I) without apoA-II [(A-I)HDL] and those containing apoA-I and apoA-II [(A-I/A-II)HDL]. ApoA-I enters the plasma as a componen
Autor:
Jian-Liang Li, Andrew C. Lake, Ying Sun, Dongmei Li, Wei Liu, Tracy Revett, Heather H. Shih, Janet E. Paulsen, Jeremy Johnson, Jae Eun Kim, Ruth E. Gimeno
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 11, Pp 2477-2487 (2005)
Adiponutrin and a related protein, adipocyte triglyceride lipase (ATGL; also known as Desnutrin), were recently described as adipocyte-specific proteins with lipid hydrolase activity. Using bioinformatics, we identified three additional Adiponutrin f
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 10, Pp 2265-2277 (2005)
The proportion of the electronegative low density lipoprotein [LDL(-)] subfraction, which is atherogenic, is increased in type 2 diabetes but is not reduced by glycemic control. Therefore, we evaluated the ability of a new technique, capillary isotac
Autor:
Christian Ehnholm, Matti Jauhiainen, Sanni Söderlund, Marja-Riitta Taskinen, Aino Soro-Paavonen
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 8, Pp 1643-1651 (2005)
University of Helsinki
University of Helsinki
Prebeta-HDL particles act as the primary acceptors of cellular cholesterol in reverse cholesterol transport (RCT). An impairment of RCT may be the reason for the increased risk of coronary heart disease (CHD) in subjects with familial low HDL. We stu
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 3, Pp 432-438 (2005)
Serum triglyceride (TG) levels are increased in extremely obese individuals, indicating abnormalities in lipid metabolism and insulin resistance. We carried out a genome scan for serum TG in 320 nuclear families segregating extreme obesity and normal
Autor:
Jukka Westerbacka, Sven-Olof Olofsson, Christopher J. Packard, Marja-Riitta Taskinen, Philip J. Stewart, Aino Soro, Bernt Wennberg, Jan Borén, Muriel J. Caslake, Martin Adiels
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 1, Pp 58-67 (2005)
The use of stable isotopes in conjunction with compartmental modeling analysis has greatly facilitated studies of the metabolism of the apolipoprotein B (apoB)-containing lipoproteins in humans. The aim of this study was to develop a multicompartment