Zobrazeno 1 - 10
of 390
pro vyhledávání: ''
Autor:
Mark W. Sleeman, Lisa M. Shihanian, George D. Yancopoulos, Joseph Lee, Andrew J. Murphy, Jonathan Cohen, Jesper Gromada, Helen H. Hobbs, Corey A. Alexa-Braun, Viktoria Gusarova, Cristopher V. Van Hout, Sara Hamon, Poulabi Banerjee, Hye In Kim, Ivory J. Mintah, Rene C. Adam
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 9, Pp 1271-1286 (2020)
Journal of Lipid Research
Journal of Lipid Research
Angiopoietin-like protein (ANGPTL)3 regulates plasma lipids by inhibiting LPL and endothelial lipase (EL). ANGPTL3 inactivation lowers LDL-C independently of the classical LDLR-mediated pathway and represents a promising therapeutic approach for indi
Autor:
Yuka Kadomatsu, Yuriko N. Koyanagi, Haruo Mikami, Michiaki Kubo, Mariko Naito, Norihiro Furusyo, Yuichiro Nishida, Asahi Hishida, Yoichi Sutoh, Atsushi Shimizu, Megumi Hara, Mineko Tsukamoto, Toshiro Takezaki, Teruhide Koyama, Chisato Shimanoe, Sakurako Katsuura-Kamano, Kenji Wakai, Tsuyoshi Hachiya, Yukihide Momozawa, Hirokazu Uemura, Naoyuki Takashima, Sadao Suzuki, Isao Oze, Rie Ibusuki, Kiyonori Kuriki, Aya Kadota, Hiroaki Ikezaki, Keitaro Tanaka, Yohko Nakamura, Masahiro Nakatochi, Nagato Kuriyama, Hiroko Nakagawa-Senda
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 1, Pp 86-94 (2020)
J Lipid Res
J Lipid Res
Few studies have investigated the interactions between HDL-C-related SNPs identified by genome-wide association (GWA) study and physical activity (PA) on HDL-C. First, we conducted a sex-stratified GWA study in a discovery sample (2,231 men and 2,431
Publikováno v:
J Lipid Res
Journal of Lipid Research, Vol 62, Iss, Pp 100149-(2021)
Lund Winther, A-M, Kristensen, K K, Kumari, A & Ploug, M 2021, ' Expression and one-step purification of active LPL contemplated by biophysical considerations ', Journal of Lipid Research, vol. 62, 100149 . https://doi.org/10.1016/j.jlr.2021.100149
Journal of Lipid Research, Vol 62, Iss, Pp 100149-(2021)
Lund Winther, A-M, Kristensen, K K, Kumari, A & Ploug, M 2021, ' Expression and one-step purification of active LPL contemplated by biophysical considerations ', Journal of Lipid Research, vol. 62, 100149 . https://doi.org/10.1016/j.jlr.2021.100149
LPL is essential for intravascular lipid metabolism and is of high medical relevance. Since LPL is notoriously unstable, there is an unmet need for a robust expression system producing high quantities of active and pure recombinant human LPL (hLPL).
Autor:
Kylie J. Schache, Kelli L. Sylvers-Davie, Ashley Segura-Roman, Brandon S.J. Davies, Alicia M. Salvi
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100112-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100112-(2021)
High plasma triglyceride (TG) levels and low HDL-C levels are risk factors for atherosclerosis and cardiovascular disease. Both plasma TG and HDL-C levels are regulated in part by the circulating inhibitor, angiopoietin-like 3 (ANGPTL3). ANGPTL3 inhi
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 6, Pp 1136-1143 (2019)
J Lipid Res
J Lipid Res
BMI is correlated with circulating metabolites, but few studies discuss other adiposity measures, and little is known about metabolomic correlates of BMI from early life. We investigated associations between different adiposity measures, BMI from chi
Autor:
Ellis M. Pearson, Ming Jing Wu, Aspen R. Gutgsell, Alan T. Remaley, Anna Wolska, Saskia B. Neher, Benjamin S. Roberts
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 12, Pp 2456-2465 (2018)
LPL is a secreted enzyme that hydrolyzes triglycerides from circulating lipoproteins. Individuals lacking LPL suffer from severe hypertriglyceridemia, a risk factor for acute pancreatitis. One potential treatment is to administer recombinant LPL as a
Autor:
Trevor J. Orchard, Alexis Nasr, Daniel J. Rader, Ian Janssen, Daniel S. McConnell, Karen A. Matthews, Sybil L. Crawford, Susan A. Everson-Rose, Jeffrey T. Billheimer, Samar R. El Khoudary, Maria M. Brooks
Publikováno v:
Journal of Lipid Research, Vol 62, Iss, Pp 100098-(2021)
Journal of Lipid Research
Journal of Lipid Research
The cardioprotective association of high-density lipoprotein cholesterol (HDL-C) may vary by menopause stage or estradiol level. We tested whether associations of comprehensive HDL metrics (HDL subclasses, phospholipid and triglyceride content, and H
Autor:
Marc Baumann, Katariina Maaninka, Minoru Tozuka, Matti Jauhiainen, Miriam Lee-Rueckert, Su Duy Nguyen, Petri T. Kovanen, Andrey Anisimov, Ilona Kareinen
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 6, Pp 945-957 (2018)
ApoA-I, the main structural and functional protein of HDL particles, is cardioprotective, but also highly sensitive to proteolytic cleavage. Here, we investigated the effect of cardiac mast cell activation and ensuing chymase secretion on apoA-I degr
Autor:
Debi K. Swertfeger, John T. Melchior, Amy S. Shah, W. Sean Davidson, Jeremy D. Furtado, Allison B. Andraski, Hailong Li, Emily I. Greve, Scott E. Street, L. Jason Lu, Frank M. Sacks, Rebecca L. Shute
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 7, Pp 1374-1385 (2017)
HDLs are a family of heterogeneous particles that vary in size, composition, and function. The structure of most HDLs is maintained by two scaffold proteins, apoA-I and apoA-II, but up to 95 other "accessory" proteins have been found associated with
Autor:
Gordon Z. Jiang, Manja Koch, Frank M. Sacks, Brianna E. Gray, Tianxi Cai, Majken K. Jensen, Jeremy D. Furtado, Anne Tjønneland, Kim Overvad
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 6, Pp 1196-1203 (2017)
Koch, M, Furtado, J D, Jiang, G Z, Gray, B E, Cai, T, Sacks, F M, Tjønneland, A, Overvad, K & Jensen, M K 2017, ' Associations of anthropometry and lifestyle factors with HDL subspecies according to apolipoprotein C-III ', Journal of Lipid Research, vol. 58, no. 6, pp. 1196-1203 . https://doi.org/10.1194/jlr.P073288
Koch, M, Furtado, J D, Jiang, G Z, Gray, B E, Cai, T, Sacks, F, Tjønneland, A, Overvad, K & Jensen, M K 2017, ' Associations of anthropometry and lifestyle factors with HDL subspecies according to apolipoprotein C-III ', Journal of Lipid Research, vol. 58, no. 6, pp. 1196-1203 . https://doi.org/10.1194/jlr.P073288
Koch, M, Furtado, J D, Jiang, G Z, Gray, B E, Cai, T, Sacks, F M, Tjønneland, A, Overvad, K & Jensen, M K 2017, ' Associations of anthropometry and lifestyle factors with HDL subspecies according to apolipoprotein C-III ', Journal of Lipid Research, vol. 58, no. 6, pp. 1196-1203 . https://doi.org/10.1194/jlr.P073288
Koch, M, Furtado, J D, Jiang, G Z, Gray, B E, Cai, T, Sacks, F, Tjønneland, A, Overvad, K & Jensen, M K 2017, ' Associations of anthropometry and lifestyle factors with HDL subspecies according to apolipoprotein C-III ', Journal of Lipid Research, vol. 58, no. 6, pp. 1196-1203 . https://doi.org/10.1194/jlr.P073288
The presence of apolipoprotein C-III (apoC-III) on high-density lipoproteins (HDL) impairs HDL's inverse association with coronary heart disease. Little is known about modifiable factors explaining variation in HDL subspecies defined according to apo