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Autor:
Chris Boesch, Katie Carr, Leanne Hodson, Alison Sleigh, Graham J. Kemp, Krishna K Chatterjee, David B. Savage, Claire Adams, Laura Watson, Soren Brage
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 60, Iss 7, Pp 1323-1332 (2019)
Journal of Lipid Research, Vol 60, Iss 7, Pp 1323-1332 (2019)
Intramyocellular lipid (IMCL) accumulation has been linked to both insulin-resistant and insulin-sensitive (athletes) states. Biochemical analysis of intramuscular triglyceride composition is confounded by extramyocellular triglycerides in biopsy sam
Autor:
Timothy J. Lyons, Arpita Basu, Maria F. Lopes-Virella, Alicia J. Jenkins, Ying Zhang, Julie A. Stoner, Richard L. Klein
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 2, Pp 310-317 (2016)
Our objective is to define differences in circulating lipoprotein subclasses between intensive versus conventional management of type 1 diabetes during the randomization phase of the Diabetes Control and Complications Trial (DCCT). NMR-determined lip
Autor:
Patrick Couture, Jean-Philippe Drouin-Chartier, Jean-Charles Hogue, Benoît Lamarche, Valéry Lemelin, André J. Tremblay
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 8, Pp 1501-1509 (2018)
Intestinal triglyceride (TG)-rich lipoproteins (TRLs) are important in the pathogenesis of atherosclerosis in insulin resistance (IR). We investigated the association of plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations with
Autor:
Takashi Matsuzaka, Takanari Gotoda, Hiroaki Suzuki, Hitoshi Shimano, Noriyuki Inoue, Naoya Yahagi, Nobuhiro Yamada, Naomi Ishigaki, Takashi Yamamoto, Akimitsu Takahashi, Kazuhisa Watanabe, Shigeru Yatoh, Yoshinori Takeuchi, Yoshimi Nakagawa, Kazuto Kobayashi
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 7, Pp 1859-1870 (2010)
Sterol-regulatory element binding protein-1c (SREBP-1c) is a transcription factor that controls lipogenesis in the liver. Hepatic SREBP-1c is nutritionally regulated, and its sustained activation causes hepatic steatosis and insulin resistance. Altho
Autor:
Alice H. Lichtenstein, Sonya J. Elder, Thomas J. Bouchard, Susan B. Roberts, Edward Saltzman, Andrew S. Greenberg, Megan A. McCrory, Paul J. Fuss, Michael C. Neale, Anastassios G. Pittas
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 9, Pp 1917-1926 (2009)
The relative influence of genetics and the environment on factors associated with cardiovascular disease (CVD) and metabolic syndrome (MetS) remains unclear. We performed model-fitting analyses to quantify genetic, common environmental, and unique en
Autor:
Karen Reue, Jennifer R. Dwyer
Publikováno v:
Journal of Lipid Research, Vol 50, Iss, Pp S109-S114 (2009)
The lipin protein family, consisting of three members, was first identified early this century. In the last few years, the lipin proteins have been shown to have important roles in glycerolipid biosynthesis and gene regulation, and mutations in the c
Autor:
Beata Lecka-Czernik, Neda Rasouli, Resat Unal, Gouri Ranganathan, Aiwei Yao-Borengasser, Irina D. Pokrovskaya, Philip A. Kern, Bounleut Phanavanh
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 11, Pp 2444-2450 (2006)
Acyl-coenzyme A:diacylglycerol transferase (DGAT), fatty acid synthetase (FAS), and LPL are three enzymes important in adipose tissue triglyceride accumulation. To study the relationship of DGAT1, FAS, and LPL with insulin, we examined adipose mRNA e
Autor:
Allan D. Sniderman, Jean-Pierre Després, Bernadette Delplanque, Charles Couillard, Katherine Cianflone, Robert Zakarian
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 1, Pp 124-131 (2004)
Postprandial plasma triglyceride (ppTG) and NEFA clearance were stratified by plasma acylation-stimulating protein (ASP) and gender to determine the contribution of fasting ASP in a normal population (70 men; 71 women). In the highest ASP tertile onl
Autor:
Johannes A. Romijn, Peter J. Voshol, Anita M. van den Hoek, Martin Muurling, Ronald P. Mensink, Louis M. Havekes, T. Hanno Pijl
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 1, Pp 9-16 (2004)
Journal of lipid research, 45(1), 9-16. American Society for Biochemistry and Molecular Biology Inc.
Journal of Lipid Research, 1, 45, 9-16
Journal of Lipid Research, 45(1), 9-16. American Society for Biochemistry and Molecular Biology, Inc.
Journal of lipid research, 45(1), 9-16. American Society for Biochemistry and Molecular Biology Inc.
Journal of Lipid Research, 1, 45, 9-16
Journal of Lipid Research, 45(1), 9-16. American Society for Biochemistry and Molecular Biology, Inc.
Obese obob mice with strong overexpression of the human apolipoprotein C1 (APOC1) exhibit excessive free fatty acid (FFA) and triglyceride (TG) levels and severely reduced body weight (due to the absence of subcutaneous adipose tissue) and skin abnor
Autor:
Francesca Pizzolo, Nicola Martinelli, Oliviero Olivieri, Roberto Corrocher, Simonetta Friso, Domenico Girelli, Elisabetta Trabetti, Pier Franco Pignatti, Chiara Stranieri, Antonella Bassi
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 12, Pp 2374-2381 (2003)
Apolipoprotein C-III (apoC-III) is a marker of triglyceride (TG)-rich lipoproteins, which are often increased in metabolic syndrome (MS). The T-455C polymorphism in the insulin-responsive element of the APOC3 gene influences TG and apoC-III levels. T