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Publikováno v:
Journal of Lipid Research, Vol 56, Iss 1, Pp 122-128 (2015)
The mechanisms by which LDLs and HDLs cross the vascular endothelium from plasma into interstitial fluid are not understood, and have never been studied in humans in vivo. We determined whether the plasma-to-lymph clearance rates of LDL and HDL confo
Autor:
F. Rached, Carolane Dauteuille, Marcio H. Miname, Laurent Camont, Carlos V. Serrano, Raul D. Santos, M. John Chapman, Marie Lhomme, Anatol Kontush, Sora Lecocq
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 12, Pp 2509-2520 (2014)
To evaluate functional and compositional properties of HDL in subjects from a kindred of genetic apoA-I deficiency, two homozygotes and six heterozygotes, with a nonsense mutation at APOA1 codon -2, Q[-2]X, were recruited together with age- and sex-m
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 11, Pp 2423-2431 (2014)
ABCA1 mediates the efflux of cholesterol and phospholipids into apoA-I to form HDL, which is important in the prevention of atherosclerosis. To develop a novel method for the evaluation of HDL formation, we prepared an apoA-I-POLARIC by labeling the
Autor:
Hannah Sexmith, John T. Melchior, Anna Heink, Scott M. Gordon, Lawrence M. Dolan, Amy S. Shah, Esmond Geh, W. Sean Davidson, Jane C. Khoury, James D. Otvos, Deborah A. Elder
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 9, Pp 1916-1923 (2017)
We aimed to determine the risk factors associated with the depletion of large HDL particles and enrichment of small HDL particles observed in adolescents with T2D. Four groups of adolescents were recruited: 1) lean insulin-sensitive (L-IS), normal BM
Autor:
Benjamin L. Emert, Ladan Vakili, James R. Springstead, Judith A. Berliner, Aldons J. Lusis, Yehudit Hasin-Brumshtein
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 8, Pp 1678-1692 (2014)
Oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phospholcholine (OxPAPC) and its component phospholipids accumulate in atherosclerotic lesions and regulate the expression of >1,000 genes, many proatherogenic, in human aortic endothelial cells (HAECs)
Autor:
Hugo A. L. Filipe, Maria João Moreno, Armindo Salvador, Luís M.B.B. Estronca, Winchil L.C. Vaz
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 6, Pp 1033-1043 (2014)
The rate of noncatalyzed transfer of cholesterol (Chol) among lipoproteins and cells in the blood is of fundamental importance as a baseline to assess the role of active transport mechanisms, but remains unknown. Here we address this gap by character
Autor:
Philip J. Barter, Kerry-Anne Rye
Publikováno v:
Journal of Lipid Research. 55:168-179
Multiple human population studies have established the concentration of high density lipoprotein (HDL) cholesterol as an independent, inverse predictor of the risk of having a cardiovascular event. Furthermore, HDLs have several well-documented funct
Autor:
Wen-Liang Song, Garret A. FitzGerald
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2586-2594 (2013)
Niacin (nicotinic acid) has been used for decades as a lipid-lowering drug. The clinical use of niacin to treat dyslipidemic conditions is limited by its side effects. Niacin, along with fibrates, are the only approved drugs which elevate high densit
Autor:
Remco Franssen, Albert K. Groen, Erik S.G. Stroes, G. Kees Hovingh, Julie Decaris, Marc K. Hellerstein, Lily Jakulj, John J.P. Kastelein, Jan Albert Kuivenhoven, Joris Koetsveld, Alexander Glass, Scott M. Turner, Jayraz Luchoomun, Menno Vergeer, Adriaan G. Holleboom
Publikováno v:
Journal of Lipid Research, 54(7), 1964-1971. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Journal of lipid research, 54(7), 1964-1971. American Society for Biochemistry and Molecular Biology Inc.
Journal of Lipid Research, Vol 54, Iss 7, Pp 1964-1971 (2013)
Journal of lipid research, 54(7), 1964-1971. American Society for Biochemistry and Molecular Biology Inc.
Journal of Lipid Research, Vol 54, Iss 7, Pp 1964-1971 (2013)
Atheroprotection by high density lipoprotein (HDL) is considered to be mediated through reverse cholesterol transport (RCT) from peripheral tissues. We investigated in vivo cholesterol fluxes through the RCT pathway in patients with low plasma high d
Autor:
Kathryn J. Moore, Mireille Ouimet
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 5, Pp 1161-1167 (2013)
High-density lipoproteins play a central role in systemic cholesterol homeostasis by stimulating the efflux of excess cellular cholesterol and transporting it to the liver for biliary excretion. HDL has long been touted as the “good cholesterol”