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of 33
pro vyhledávání: ''
Autor:
Graeme I. Lancaster, Denis Sviridov, Nigora Mukhamedova, Takahiro Kameda, Gerard Pernes, Peter J. Meikle, Ryunosuke Ohkawa, Boris L. Vaisman, Andrew J. Murphy, Ayuko Hara, Ying Fu, Michael Ditiatkovski, Shao-Jui Lai, Paul J. Nestel, Alan T. Remaley, Hann Low, Dmitri Sviridov, Minoru Tozuka, Yuna Horiuchi, Mai Sasaoka, Azusa Yamazaki
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1577-1588 (2020)
J Lipid Res
J Lipid Res
Lipoproteins play a key role in transport of cholesterol to and from tissues. Recent studies have also demonstrated that red blood cells (RBCs), which carry large quantities of free cholesterol in their membrane, play an important role in reverse cho
Autor:
Yan Liu, Richard E. Morton
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 8, Pp 1168-1179 (2020)
J Lipid Res
J Lipid Res
Cholesteryl ester transfer protein (CETP) facilitates the net transfer of cholesteryl esters (CEs) and TGs between lipoproteins, impacting the metabolic fate of these lipoproteins. Previous studies have shown that a CETP antibody can alter CETP's pre
Autor:
Naoko Sawada, Toshihiro Aiuchi, Yuji Hamazaki, Rina Kato, Masaki Kikuchi, Shinji Koba, Hiroyuki Itabe, Sanju Iwamoto, Takashi Takaki, Takashi Obama
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 6, Pp 816-829 (2020)
J Lipid Res
J Lipid Res
Oxidized LDL (oxLDL) is a known risk factor for atherogenesis. This study aimed to reveal structural features of oxLDL present in human circulation related to atherosclerosis. When LDL was fractionated on an anion-exchange column, in vivo-oxLDL, dete
Autor:
Alfred Tau Liang Gan, Qiao Fan, Ian Yeo, Rajendra S. Apte, Tien Yin Wong, Chiea Chuen Khor, E. Shyong Tai, Ranjana Mathur, Miao Ling Chee, Ching-Yu Cheng, Chui Ming Gemmy Cheung
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 58, Iss 9, Pp 1785-1796 (2017)
Journal of Lipid Research, Vol 58, Iss 9, Pp 1785-1796 (2017)
Disturbance in lipid metabolism has been suggested as a major pathogenic factor for age-related macular degeneration (AMD). Conventional lipid measures have been inconsistently associated with AMD. Other factors that can alter lipid metabolism includ
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 12, Pp 2138-2149 (2016)
Oxidative stress and inflammation, which involve a dramatic increase in serum amyloid A (SAA) levels, are critical in the development of atherosclerosis. Most SAA circulates on plasma HDL particles, altering their cardioprotective properties. SAA-enr
Autor:
Zsuzsanna Kuklenyik, Katrin Niisuke, Katalin V. Horvath, Michael S. Gardner, Bela F. Asztalos, Christopher A. Toth
Publikováno v:
J Lipid Res
Journal of Lipid Research, Vol 61, Iss 3, Pp 306-315 (2020)
Journal of Lipid Research, Vol 61, Iss 3, Pp 306-315 (2020)
The composition-function relationship of HDL particles and its effects on the mechanisms driving coronary heart disease (CHD) is poorly understood. We tested the hypothesis that the functionality of HDL particles is significantly influenced by their
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 60, Iss 3, Pp 550-565 (2019)
Journal of Lipid Research, Vol 60, Iss 3, Pp 550-565 (2019)
Fibroblast growth factor (FGF)19, an endocrine hormone produced in the gut, acts in the liver to control bile acid synthesis. NGM282, an engineered FGF19 analog, is currently in clinical development for treating nonalcoholic steatohepatitis. However,
Autor:
Richard Charnigo, Nancy R. Webb, Joanne M. Wroblewski, Deneys R. van der Westhuyzen, Frederick C. de Beer, Ailing Ji, Myung Hee Kim, Maria C. de Beer
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 6, Pp 969-979 (2016)
The acute phase (AP) reactant serum amyloid A (SAA), an HDL apolipoprotein, exhibits pro-inflammatory activities, but its physiological function(s) are poorly understood. Functional differences between SAA1.1 and SAA2.1, the two major SAA isoforms, a
Autor:
Loren E. Smith, Amy S. Shah, W. Gray Jerome, Alan T. Remaley, Jamie Morris, Scott E. Street, John T. Melchior, Allison L Cooke, W. Sean Davidson, Andrew B. Herr, Thomas B. Thompson, Rong Huang, Jere P. Segrest
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 7, Pp 1244-1255 (2018)
APOA1 is the most abundant protein in HDL. It modulates interactions that affect HDL';s cardioprotective functions, in part via its activation of the enzyme, LCAT. On nascent discoidal HDL, APOA1 comprises 10 α-helical repeats arranged in an anti-pa
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 8, Pp 1531-1542 (2015)
Serum amyloid A (SAA) is an acute-phase protein that circulates mainly on plasma HDL. SAA interactions with its functional ligands and its pathogenic deposition in reactive amyloidosis depend, in part, on the structural disorder of this protein and i