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of 4
pro vyhledávání: '"59"'
Autor:
Guolin Li, Kristopher W. Krausz, Chad Brocker, Jiang Yue, Frank J. Gonzalez, Donghwan Kim, Tingting Yan, Thomas J. Velenosi, Daxesh P. Patel
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 11, Pp 2140-2152 (2018)
PPARα (PPARA), expressed in most oxidative tissues, is a major regulator of lipid homeostasis; hepatic PPARA plays a critical role during the adaptive fasting response by promoting FA oxidation (FAO). To clarify whether extrahepatic PPARA activity c
Autor:
Marisa R. Morrow, Brian G. Sutherland, Jane Y. Edwards, Dawn E. Telford, Amy C. Burke, Maria Drangova, Cynthia G. Sawyez, Murray W. Huff
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1714-1728 (2018)
Medical Biophysics Publications
Bone and Joint Institute
Medical Biophysics Publications
Bone and Joint Institute
Copyright © 2018 Burke et al. Obesity and its associated metabolic dysfunction and cardiovascular disease risk represent a leading cause of adult morbidity worldwide. Currently available pharmacological therapies for obesity have had limited success
Regulation of mitochondrial trifunctional protein modulates nonalcoholic fatty liver disease in mice
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 6, Pp 967-973 (2018)
Journal of Lipid Research
Journal of Lipid Research
Mitochondrial trifunctional protein (MTP) plays a critical role in the oxidation of long-chain fatty acids. We previously reported that aging mice (>9 months old) heterozygous for an MTP defect (MTP+/−) develop nonalcoholic fatty liver disease (NAF
Autor:
Jiamin Yu, Bing Luan, Bingxin Xu, Yang Xiao, Chao Zhang, Jindong Yao, Xinchen Qiu, Zhen-Ning Zhang, Fangfei Guo, Jian Li, Haiyan He, Sihan Lv, Junkun Jiang
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 2, Pp 330-338 (2018)
Disregulation of fatty acid oxidation, one of the major mechanisms for maintaining hepatic lipid homeostasis under fasting conditions, leads to hepatic steatosis. Although obesity and type 2 diabetes-induced endoplasmic reticulum (ER) stress contribu