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Publikováno v:
Journal of lipid research. 63(9)
The microsomal triglyceride transfer protein (MTP) is essential for the secretion of apolipoprotein B (apoB)48- and apoB100-containing lipoproteins in the intestine and liver, respectively. Loss of function mutations in MTP cause abetalipoproteinemia
Publikováno v:
Journal of lipid research. 63(10)
Low circulating concentrations of insulin-like growth factor binding protein-2 (IGFBP-2) have been associated with dyslipidemia, notably with high triglyceride (TG) levels. However, the determinants by which IGFBP-2 influences lipoprotein metabolism,
Autor:
Kirill Zhudenkov, Bengt Hamrén, Rasmus Jansson-Löfmark, Eva Hurt-Camejo, Catarina Nilsson, Gabriel Helmlinger, Stanko Skrtic, Kirill Peskov, Victor Sokolov
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 9, Pp 1610-1621 (2019)
Journal of Lipid Research
Journal of Lipid Research
Since the discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9) as an attractive target in the treatment of hypercholesterolemia, multiple anti-PCSK9 therapeutic modalities have been pursued in drug development. The objective of this res
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 1, Pp 111-120 (2019)
Journal of Lipid Research
Journal of Lipid Research
We investigated whether, in view of its activity being expressed on both aspects of the endoplasmic reticulum (ER; dual membrane topology), diacylglycerol acyltransferase 1 (DGAT1) plays a distinctive role in determining the triglyceride (TAG) conten
Autor:
Hella A. Bolck, Arnold von Eckardstein, Peter Schraml, Srividya Velagapudi, Mustafa Yalcinkaya, Lucia Rohrer, Holger Moch
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 59, Iss 11, Pp 2188-2201 (2018)
Journal of Lipid Research, Vol 59, Iss 11, Pp 2188-2201 (2018)
Clear-cell renal cell carcinomas (ccRCCs) are characterized by inactivation of the von Hippel-Lindau (VHL) gene and intracellular lipid accumulation by unknown pathomechanisms. The immunochemical analysis of 356 RCCs revealed high abundance of apoA-I
Autor:
Jacqueline DeGraaf, Patrick Couture, Seth S. Martin, George Thanassoulis, Patrick R. Lawler, John T. Wilkins, William C. Cromwell, Allan D. Sniderman
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 7, Pp 1266-1275 (2018)
Triglycerides are the conventional tool to measure VLDLs, whereas LDL cholesterol (LDL-C) is the conventional tool to measure LDLs. Multiple epidemiological studies, including a series of genetically based analyses, have demonstrated that cardiovascu
Autor:
Huda Salem, Nathalie Saint-Pierre, May Faraj, Alexis Baass, Hanny Wassef, Robert Dufour, Annie Tardif, Simon Bissonnette
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 5, Pp 1466-1476 (2013)
Delayed clearance of triglyceride-rich lipoprotein (TRL) by white adipose tissue (WAT) promotes hypertriglyceridemia and elevated apoB-lipoproteins, which are primarily in the form of LDL. This study examines whether LDL promotes delayed clearance of
Autor:
Hayes M. Dansky, Joseph Orr, Kathleen Wojnooski, Julie Mabalot Luk, Matt S. Anderson, Amy O. Johnson-Levonas, Cathy Anne Pinto, John A. Wagner, J. Casey Geaney, Yang Liu, Ronald M. Krauss
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 3, Pp 540-547 (2012)
We investigated the effects of the cholesteryl ester (CE) transfer protein inhibitor anacetrapib (ANA) on plasma lipids, lipoprotein subfraction concentrations, and lipoprotein composition in 30 healthy individuals. Participants (n = 30) were randomi
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 3, Pp 566-571 (2011)
We examined the association between rate of cholesterol esterification in plasma depleted of apolipoprotein B-containing lipoproteins (FER(HDL)), atherogenic index of plasma (AIP) [(log (TG/HDL-C)], concentrations, and size of lipoproteins and change
Autor:
Iulia Iatan, Matti Jauhiainen, Christian Ehnholm, Larbi Krimbou, Haley Cochrane, Jacques Genest, Dana Bailey, Isabelle Ruel, Anouar Hafiane
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 4, Pp 785-797 (2010)
The specifics of nascent HDL remodeling within the plasma compartment remain poorly understood. We developed an in vitro assay to monitor the lipid transfer between model nascent HDL (LpA-I) and plasma lipoproteins. Incubation of alpha-(125)I-LpA-I w