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Autor:
Stephen J. Demosky, G D Talley, Jeffrey M. Hoeg, Silvia Santamarina-Fojo, Boris L. Vaisman, Jian Wang, H. Bryan Brewer, Margaret E. Brousseau
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 8, Pp 1558-1567 (1998)
Familial hypercholesterolemia (FH), a disease caused by a variety of mutations in the low density lipopro- tein receptor (LDLr) gene, leads not only to elevated LDL- cholesterol (C) concentrations but to reduced high density lipoprotein (HDL)-C and a
Publikováno v:
Journal of Lipid Research, Vol 37, Iss 11, Pp 2372-2382 (1996)
Guinea pigs were fed 15% (w/W) fat, high in lauric and myristic acids, a diet known to produce hypercholesterolemia in these animals. The diet was given alone or in combination with four doses of atorvastatin equivalent to 1, 3, 10, and 20 mg/kg per