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Publikováno v:
Journal of Lipid Research, Vol 59, Iss 2, Pp 391-399 (2018)
Journal of lipid research, vol 59, iss 2
Journal of lipid research, vol 59, iss 2
Elevated plasma LDL cholesterol is the dominant risk factor for the development of atherosclerosis and cardiovascular disease. Deficiency in the LDL receptor (LDLR) is a major cause of familial hypercholesterolemia in humans, and the LDLR knockout mo
Autor:
Stephen J. Demosky, G D Talley, Jeffrey M. Hoeg, Silvia Santamarina-Fojo, Boris L. Vaisman, Jian Wang, H. Bryan Brewer, Margaret E. Brousseau
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 8, Pp 1558-1567 (1998)
Familial hypercholesterolemia (FH), a disease caused by a variety of mutations in the low density lipopro- tein receptor (LDLr) gene, leads not only to elevated LDL- cholesterol (C) concentrations but to reduced high density lipoprotein (HDL)-C and a