Zobrazeno 1 - 7
of 7
pro vyhledávání: '"59"'
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 2, Pp 391-399 (2018)
Journal of lipid research, vol 59, iss 2
Journal of lipid research, vol 59, iss 2
Elevated plasma LDL cholesterol is the dominant risk factor for the development of atherosclerosis and cardiovascular disease. Deficiency in the LDL receptor (LDLR) is a major cause of familial hypercholesterolemia in humans, and the LDLR knockout mo
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 12, Pp 2349-2359 (2018)
Dietary fat absorption takes place in the intestine, and the liver mobilizes endogenous fat to other tissues by synthesizing lipoproteins that require apoB and microsomal triglyceride transfer protein (MTP). Dietary fat triggers the synthesis of oleo
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 7, Pp 1114-1131 (2018)
Cholesterol is required for maintenance of plasma membrane fluidity and integrity and for many cellular functions. Cellular cholesterol can be obtained from lipoproteins in a selective pathway of HDL-cholesteryl ester (CE) uptake without parallel apo
Autor:
Alaa Sirwi, M. Mahmood Hussain
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 7, Pp 1094-1102 (2018)
A better understanding of intracellular lipoprotein assembly may help identify proteins with important roles in lipid disorders. apoB-containing lipoproteins (B-lps) are macromolecular lipid and protein micelles that act as specialized transport vehi
Autor:
Daniel J. Rader, Naqi Haider, Venkata R M Chavali, Michael C. Phillips, Nicholas N. Lyssenko, Wanzhen Jiao, Antonino Picataggi, Eleonora Cipollari
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 1927-1939 (2018)
Cholesterol-containing soft drusen and subretinal drusenoid deposits (SDDs) occur at the basolateral and apical side of the retinal pigment epithelium (RPE), respectively, in the chorioretina and are independent risk factors for late age-related macu
Autor:
Patrick Couture, Jean-Philippe Drouin-Chartier, Jean-Charles Hogue, Benoît Lamarche, Valéry Lemelin, André J. Tremblay
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 8, Pp 1501-1509 (2018)
Intestinal triglyceride (TG)-rich lipoproteins (TRLs) are important in the pathogenesis of atherosclerosis in insulin resistance (IR). We investigated the association of plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations with
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 59, Iss 10, Pp 1987-2000 (2018)
Journal of Lipid Research, Vol 59, Iss 10, Pp 1987-2000 (2018)
Abnormal plasma apolipoprotein levels are consistently implicated in CVD risk. Although 30% to 60% of their interindividual variability is genetic, common genetic variants explain only 10% to 20% of these differences. Rare genetic variants may be maj