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Publikováno v:
Journal of Lipid Research, Vol 57, Iss 11, Pp 2088-2094 (2016)
Sphingosine-1-phosphate (S1P) is present in the blood plasma and acts as a pivotal intercellular signal transmitter in the immune system by recruiting lymphocytes from the thymus and secondary lymphoid tissues. The plasma S1P concentration is maintai
Autor:
Robin F. Irvine
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 11, Pp 1987-1994 (2016)
The diverse family of inositol lipids is now known to be central to many aspects of cell biology. The route from the first discovery of inositol to our present day knowledge of inositol lipids spans more than 150 years and is long and complex. This i
Autor:
Toru Uyama, Natsuo Ueda, Zahir Hussain, Katsuhisa Kawai, Nobukazu Araki, Iffat Ara Sonia Rahman, Kazuhito Tsuboi
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 11, Pp 2051-2060 (2016)
N-Acylphosphatidylethanolamines (NAPEs) are a class of glycerophospholipids, which are known as precursors for different bioactive N-acylethanolamines. We previously reported that phospholipase A/acyltransferase-1 (PLAAT-1), which was originally foun
Autor:
Zdzislaw M. Szulc, Edward L. Hogan, Maria Podbielska, Narayan R. Bhat, Alicja Bielawska, Ewa Kurowska, Jacek Bielawski
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 11, Pp 2028-2039 (2016)
Th1 pro-inflammatory cytokines, i.e., TNF-α and IFN-γ, in combination are known to induce cell death in several cell types, including oligodendrocytes, but the mechanism of their synergistic cytotoxicity is unclear. Although ceramide (Cer) has been
Autor:
Tomoko Sayano, Kazuki Nakajima, Hisako Akiyama, Yoshiyuki Itoh, Yoshiki Yamaguchi, Yoshio Hirabayashi, Peter Greimel, Yoko Ohashi
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 11, Pp 2061-2072 (2016)
To date, sterylglucosides have been reported to be present in various fungi, plants, and animals. In bacteria, such as Helicobacter pylori, proton NMR spectral analysis of isolated 1-O-cholesteryl-β-d-glucopyranoside (GlcChol) demonstrated the prese
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 57, Iss 12, Pp 2225-2234 (2016)
Journal of Lipid Research, Vol 57, Iss 12, Pp 2225-2234 (2016)
Phosphatidylcholine (PC) species in human plasma are used as biomarkers of disease. PC biomarkers are often limited by the inability to separate isobaric PCs. In this work, we developed a targeted shotgun approach for analysis of isobaric and isomeri
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 57, Iss 10, Pp 1845-1853 (2016)
Journal of Lipid Research, Vol 57, Iss 10, Pp 1845-1853 (2016)
Oxysterols are 27-carbon oxidized derivatives of cholesterol or by-products of cholesterol biosynthesis that can induce cell apoptosis in addition to a number of other bioactions. However, the mechanisms underlying this cytotoxicity are not completel
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 10, Pp 1934-1947 (2016)
The demand to study the cellular localization of specific lipids has led to recent advances in lipid probes and microscopy. Alkyne lipids bear a small, noninterfering tag and can be detected upon click reaction with an azide-coupled reporter. Fluores
Autor:
Roberto Romero, Adi L. Tarca, Nikolina Docheva, Piya Chaemsaithong, Tinnakorn Chaiworapongsa, Kenneth V. Honn, Zhonghui Xu, Juan Pedro Kusanovic, Senlin Zhou, Ricardo Gomez, Krishna Rao Maddipati
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 10, Pp 1906-1916 (2016)
Clinical chorioamnionitis at term (TCC) is the most common obstetrical infliction diagnosed in labor and delivery units worldwide and is associated with a substantial increase in maternal and neonatal morbidity and mortality. This obstetrical complic
Autor:
Ronald M. Krauss, Patty W. Siri-Tarino
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 10, Pp 1771-1777 (2016)
Journal of lipid research, vol 57, iss 10
Journal of lipid research, vol 57, iss 10
This review outlines major milestones in the first four decades of lipoprotein research beginning with their discovery nearly 90 years ago. It focuses on the contributions of some of the key investigators during this era, and findings that set the st