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Autor:
Ajit Regmi, Mariam Ehsani, Yue-Wei Qian, M. Jane Luo, Eugene Y. Zhen, William C. Roell, Robert J. Konrad, Haihong Guo, Robert W. Siegel, Ferdinand M. van’t Hooft, Thomas G. Pottanat, Ruth E. Gimeno, Yan Q. Chen
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 61, Iss 8, Pp 1203-1220 (2020)
Journal of Lipid Research, Vol 61, Iss 8, Pp 1203-1220 (2020)
Angiopoietin-like protein (ANGPTL)8 has been implicated in metabolic syndrome and reported to regulate adipose FA uptake through unknown mechanisms. Here, we studied how complex formation of ANGPTL8 with ANGPTL3 or ANGPTL4 varies with feeding to regu
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 8, Pp 1161-1167 (2020)
J Lipid Res
J Lipid Res
The risk for metabolic disease, including metabolic syndrome, insulin resistance, and diabetes, increases with age. Altered plasma TG metabolism and changes in fatty acid partitioning are also major contributors to metabolic disease. Plasma TG metabo
Autor:
Salman Azhar, Wei Wang, Wen-Jun Shen, Qui Shuo, Yiqiang Zhang, Xiaoming Hou, Kathrin B. Hasbargen, Fredric B. Kraemer, David A. Bernlohr
Publikováno v:
J Lipid Res
Adipocytes take up long chain FAs through diffusion and protein-mediated transport, whereas FA efflux is considered to occur by diffusion. To identify potential membrane proteins that are involved in regulating FA flux in adipocytes, the expression l
Autor:
Fredrick O. Onono, Guogen Mao, Andrew J. Morris, Yu Li, Courtney Hammill, Baoxiang Yan, Maria P. Kraemer, Susan S. Smyth
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 11, Pp 1818-1828 (2019)
J Lipid Res
J Lipid Res
Lysophosphatidic acids (LPAs) are bioactive radyl hydrocarbon-substituted derivatives of glycerol 3-phosphate. LPA metabolism and signaling are implicated in heritable risk of coronary artery disease. Genetic and pharmacological inhibition of these p
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 10, Pp 1720-1732 (2019)
J Lipid Res
J Lipid Res
Insulin resistance is a major risk factor for numerous diseases, including type 2 diabetes and cardiovascular disease. These disorders have dramatically increased in incidence with modern life, suggesting that excess nutrients and obesity are major c
Autor:
W. Reid Bolus, Alyssa H. Hasty
Publikováno v:
J Lipid Res
Journal of Lipid Research, Vol 60, Iss 10, Pp 1698-1709 (2019)
Journal of Lipid Research, Vol 60, Iss 10, Pp 1698-1709 (2019)
A critical contributor to the health consequences of the obesity epidemic is dysregulated adipose tissue (AT) homeostasis. While white, brown, and beige AT function is altered in obesity-related disease, white AT is marked by progressive inflammation
Autor:
Philipp E. Scherer, Jan-Bernd Funcke
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 10, Pp 1648-1697 (2019)
J Lipid Res
J Lipid Res
The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue-secreted signaling mediators (adipokines) have been identified since th
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 4, Pp 734-740 (2019)
Journal of Lipid Research
Journal of Lipid Research
Although counterregulatory hormones and mediators of the fight-or-flight responses are well defined at many levels, how energy stores per se are integrated into this system remains an enigmatic question. Recent years have seen the adipose tissue beco
Autor:
Thomas L. Saunders, Yiping Tu, Christopher M. Allan, Norma P. Sandoval, Darren A. Cusanovich, Ty D. Troutman, Loren G. Fong, Anne P. Beigneux, Eniko Sajti, Casey E. Romanoski, Patrick J. Heizer, Jazmin E. Morales, Stephen G. Young, Rachel S. Jung
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 4, Pp 869-879 (2019)
Journal of lipid research, vol 60, iss 4
Journal of lipid research, vol 60, iss 4
Glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1 (GPIHBP1), the protein that shuttles LPL to the capillary lumen, is essential for plasma triglyceride metabolism. When GPIHBP1 is absent, LPL remains stranded within t
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 4, Pp 856-868 (2019)
Treatment with PPARγ agonists in vivo improves human adipocyte metabolism, but the cellular mechanisms and possible depot differences in responsiveness to their effects are poorly understood. To examine the ex vivo metabolic effects of rosiglitazone