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Autor:
Benjamin M. Abraham, Felix Zhou, Edward A. Fisher, Johannes von Lintig, Ivan Pinos, Jaume Amengual, Tessa J. Barrett, Xiaoyun Wu
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 11, Pp 1491-1503 (2020)
J Lipid Res
J Lipid Res
Atherosclerosis is characterized by the pathological accumulation of cholesterol-laden macrophages in the arterial wall. Atherosclerosis is also the main underlying cause of CVDs, and its development is largely driven by elevated plasma cholesterol.
Autor:
Yan Liu, Richard E. Morton
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 8, Pp 1168-1179 (2020)
J Lipid Res
J Lipid Res
Cholesteryl ester transfer protein (CETP) facilitates the net transfer of cholesteryl esters (CEs) and TGs between lipoproteins, impacting the metabolic fate of these lipoproteins. Previous studies have shown that a CETP antibody can alter CETP's pre
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 1, Pp 100144-(2022)
Journal of Lipid Research, 63(1):100144. American Society for Biochemistry and Molecular Biology, Inc.
Journal of Lipid Research, 63(1):100144. American Society for Biochemistry and Molecular Biology, Inc.
Lipoprotein lipase (LPL) is a key player in plasma triglyceride metabolism. Consequently, LPL is regulated by several proteins during synthesis, folding, secretion, and transport to its site of action at the luminal side of capillaries, as well as du
Autor:
Jessie B. Hoffman, Bernhard Hennig, Maria P. Kraemer, Andrew J. Morris, Pan Deng, Xu-Sheng Li, Chunyan Wang, Michael C. Petriello
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 1, Pp 45-53 (2020)
J Lipid Res
J Lipid Res
Elevated circulating levels of ceramides (Cers) are associated with increased risk of cardiometabolic diseases, and Cers may play a causative role in metabolic dysfunction that precedes cardiac events, such as mortality as a result of coronary artery
Autor:
Paul Ramm Sander, Daniela Baumstark, Fritz Huber, Werner Kremer, Hans Robert Kalbitzer, Renate Kirchhoefer, Alfred Boettcher, Gerd Schmitz, Christina Schreier
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 9, Pp 1516-1534 (2019)
J Lipid Res
J Lipid Res
NMR-based quantification of human lipoprotein (sub)classes is a powerful high-throughput method for medical diagnostics. We evaluated select proton NMR signals of serum lipoproteins for elucidating the physicochemical features and the absolute NMR vi
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 1, Pp 111-120 (2019)
Journal of Lipid Research
Journal of Lipid Research
We investigated whether, in view of its activity being expressed on both aspects of the endoplasmic reticulum (ER; dual membrane topology), diacylglycerol acyltransferase 1 (DGAT1) plays a distinctive role in determining the triglyceride (TAG) conten
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 12, Pp 2349-2359 (2018)
Dietary fat absorption takes place in the intestine, and the liver mobilizes endogenous fat to other tissues by synthesizing lipoproteins that require apoB and microsomal triglyceride transfer protein (MTP). Dietary fat triggers the synthesis of oleo
Publikováno v:
Journal of Lipid Research, Vol 62, Iss, Pp 100093-(2021)
Journal of Lipid Research
Journal of Lipid Research
The liver is the central organ regulating cholesterol synthesis, storage, transport, and elimination. Mouse carboxylesterase 1d (Ces1d) and its human ortholog CES1 have been described to possess lipase activity and play roles in hepatic triacylglycer
Autor:
Jacqueline DeGraaf, Patrick Couture, Seth S. Martin, George Thanassoulis, Patrick R. Lawler, John T. Wilkins, William C. Cromwell, Allan D. Sniderman
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 7, Pp 1266-1275 (2018)
Triglycerides are the conventional tool to measure VLDLs, whereas LDL cholesterol (LDL-C) is the conventional tool to measure LDLs. Multiple epidemiological studies, including a series of genetically based analyses, have demonstrated that cardiovascu
Autor:
Michael E. Lassman, Wahida Karmally, John A. Wagner, Patricia Jumes, Amanda Baer, Gissette Reyes-Soffer, John S. Millar, Soumia Aoujil, David E. Gutstein, Yang Liu, Emile M. deGoma, Richard L. Dunbar, Daniel J. Rader, Stephen Holleran, Hashmi Rafeek, Tiffany Thomas, Rajasekhar Ramakrishnan, Daniel S. Donovan, Henry N. Ginsberg, Taylor Standiford, Joseph C. Obunike
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 6, Pp 1214-1220 (2017)
Cholesteryl ester transfer protein (CETP) mediates the transfer of HDL cholesteryl esters for triglyceride (TG) in VLDL/LDL. CETP inhibition, with anacetrapib, increases HDL-cholesterol, reduces LDL-cholesterol, and lowers TG levels. This study descr