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Autor:
Yan Liu, Richard E. Morton
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 8, Pp 1168-1179 (2020)
J Lipid Res
J Lipid Res
Cholesteryl ester transfer protein (CETP) facilitates the net transfer of cholesteryl esters (CEs) and TGs between lipoproteins, impacting the metabolic fate of these lipoproteins. Previous studies have shown that a CETP antibody can alter CETP's pre
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 1, Pp 100144-(2022)
Journal of Lipid Research, 63(1):100144. American Society for Biochemistry and Molecular Biology, Inc.
Journal of Lipid Research, 63(1):100144. American Society for Biochemistry and Molecular Biology, Inc.
Lipoprotein lipase (LPL) is a key player in plasma triglyceride metabolism. Consequently, LPL is regulated by several proteins during synthesis, folding, secretion, and transport to its site of action at the luminal side of capillaries, as well as du
Autor:
Calvin Yeang, Marlys L. Koschinsky, Nicholas J. Viney, Joseph L. Witztum, Sotirios Tsimikas, Tanya T. Marar, Shuting Xia, Michael B. Boffa
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 12, Pp 2082-2089 (2019)
J Lipid Res
Journal of lipid research, vol 60, iss 12
J Lipid Res
Journal of lipid research, vol 60, iss 12
It is postulated that lipoprotein (a) [Lp(a)] inhibits fibrinolysis, but this hypothesis has not been tested in humans due to the lack of specific Lp(a) lowering agents. Patients with elevated Lp(a) were randomized to antisense oligonucleotide [IONIS
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 11, Pp 1868-1879 (2019)
J Lipid Res
J Lipid Res
Cholesteryl ester transfer protein (CETP) regulates intravascular lipoprotein metabolism. In vitro studies indicate that ApoF alters CETP function by inhibiting its activity with LDL. To explore in vivo the complexities driving ApoF’s effects on CE
Autor:
Fredrick O. Onono, Guogen Mao, Andrew J. Morris, Yu Li, Courtney Hammill, Baoxiang Yan, Maria P. Kraemer, Susan S. Smyth
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 11, Pp 1818-1828 (2019)
J Lipid Res
J Lipid Res
Lysophosphatidic acids (LPAs) are bioactive radyl hydrocarbon-substituted derivatives of glycerol 3-phosphate. LPA metabolism and signaling are implicated in heritable risk of coronary artery disease. Genetic and pharmacological inhibition of these p
Autor:
Paul Ramm Sander, Daniela Baumstark, Fritz Huber, Werner Kremer, Hans Robert Kalbitzer, Renate Kirchhoefer, Alfred Boettcher, Gerd Schmitz, Christina Schreier
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 9, Pp 1516-1534 (2019)
J Lipid Res
J Lipid Res
NMR-based quantification of human lipoprotein (sub)classes is a powerful high-throughput method for medical diagnostics. We evaluated select proton NMR signals of serum lipoproteins for elucidating the physicochemical features and the absolute NMR vi
Autor:
Thomas L. Saunders, Yiping Tu, Christopher M. Allan, Norma P. Sandoval, Darren A. Cusanovich, Ty D. Troutman, Loren G. Fong, Anne P. Beigneux, Eniko Sajti, Casey E. Romanoski, Patrick J. Heizer, Jazmin E. Morales, Stephen G. Young, Rachel S. Jung
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 4, Pp 869-879 (2019)
Journal of lipid research, vol 60, iss 4
Journal of lipid research, vol 60, iss 4
Glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1 (GPIHBP1), the protein that shuttles LPL to the capillary lumen, is essential for plasma triglyceride metabolism. When GPIHBP1 is absent, LPL remains stranded within t
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 12, Pp 2339-2348 (2018)
Lipoprotein glomerulopathy (LPG) is a rare renal disease, characterized by lipoprotein thrombi in glomerular capillaries. A series of apoE mutations have been associated with LPG development. We previously showed that three mutants based on apoE3 seq
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 12, Pp 2349-2359 (2018)
Dietary fat absorption takes place in the intestine, and the liver mobilizes endogenous fat to other tissues by synthesizing lipoproteins that require apoB and microsomal triglyceride transfer protein (MTP). Dietary fat triggers the synthesis of oleo
Autor:
Neale D. Ridgway, Jonghwa Lee
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 1940-1950 (2018)
Intracellular lipid droplets (LDs) supply fatty acids for energy, membrane biogenesis, and lipoprotein secretion. The surface monolayer of LDs is composed of phospholipids, primarily phosphatidylcholine (PC), that stabilize the neutral lipid core of