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Publikováno v:
Journal of Lipid Research, Vol 46, Iss 10, Pp 2265-2277 (2005)
The proportion of the electronegative low density lipoprotein [LDL(-)] subfraction, which is atherogenic, is increased in type 2 diabetes but is not reduced by glycemic control. Therefore, we evaluated the ability of a new technique, capillary isotac
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 10, Pp 2214-2220 (2005)
Chylomicron remnants have been suggested to be involved in the development of atherosclerosis. To investigate the mechanisms of chylomicron remnant-induced atherosclerosis, we prepared cholesterol (Chol)-containing emulsion particles as models for ch
Autor:
Jose Friburg, Maud Chétiveaux, Anne-Laure Jarnoux, Yassine Zair, Nabil G. Seidah, Philippe Costet, Marcelo Amar, Michel Krempf, Khadija Ouguerram, Florent Lalanne, H. Bryan Brewer, Gilles Lambert
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 6, Pp 1312-1319 (2005)
Mutations in Proprotein Convertase Subtilisin Kexin 9 (PCSK9) have been associated with autosomal dominant hypercholesterolemia. In vivo kinetic studies indicate that LDL catabolism was impaired and apolipoprotein B (apoB)-containing lipoprotein synt
Autor:
Romain Vidal, Sylvie Demignot, Odile Texier, Jean Chambaz, Monique Rousset, Jean-Marc Lacorte, Sandra J. Hernandez-Vallejo, Thomas Pauquai
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 2, Pp 258-268 (2005)
Decrease of plasma lipid levels by polyphenols was linked to impairment of hepatic lipoprotein secretion. However, the intestine is the first epithelium that faces dietary compounds, and it contributes to lipid homeostasis by secreting triglyceride-r
Autor:
Medha Manchekar, Nassrin Dashti, Gattadahalli M. Anantharamaiah, Geeta Datta, Manjula Chaddha
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 10, Pp 1919-1928 (2004)
Class A peptides inhibit atherosclerosis and protect cells from class L peptide-mediated lysis. Because the cytolytic process is concentration dependent, we hypothesized that at certain concentrations both classes of peptides exert similar effect(s)
Autor:
Monica H. Farkas, MacRae F. Linton, Larry L. Swift, Virginia L. Shepherd, Sergio Fazio, Karl H. Weisgraber
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 8, Pp 1546-1554 (2004)
A portion of apolipoprotein E (apoE) internalized by hepatocytes is spared degradation and is recycled. To investigate the intracellular routing of recycling apoE, primary hepatocyte cultures from LDL receptor-deficient mice and mice deficient in rec
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 8, Pp 1572-1579 (2004)
The effect of frozen storage on lipoprotein distribution of apolipoprotein C-III (apoC-III) and apoE was investigated by measuring apoC-III and apoE by ELISA in HDL and apoB-containing lipoproteins of human plasma samples (n = 16) before and after 2
Autor:
Victor A. Drover, Timothy C. Trischuk, Ricky Agnihotri, Samuel Ho, Daisy Sahoo, Luis B. Agellon, Teddy Chan, Richard Lehner, Giovanna Chimini, Gordon A. Francis
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 6, Pp 1122-1131 (2004)
High levels of expression of the ATP binding cassette transporter Al (ABCA1) in the liver and the need to over- or underexpress hepatic ABCA1 to impact plasma HDL levels in mice suggest a major role of the liver in HDL formation and in determining ci
Autor:
Philippe Moulin, François Berthezène, Geesje M. Dallinga-Thie, Valérie Pruneta-Deloche, Agnès Sassolas, Gabriel Ponsin
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 5, Pp 859-865 (2004)
Journal of lipid research, 45(5), 859-865. American Society for Biochemistry and Molecular Biology Inc.
Journal of lipid research, 45(5), 859-865. American Society for Biochemistry and Molecular Biology Inc.
Postprandial lipid metabolism is largely dependent upon lipoprotein lipase (LPL), which hydrolyses triglycerides (TGs). The time course of LPL activity in the postprandial state following a single meal has never been studied, because its determinatio
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 5, Pp 839-848 (2004)
Apolipoprotein E (apoE)/ABCA1 interactions were investigated in human intact fibroblasts induced with 22(R)-hydroxycholesterol and 9-cis-retinoic acid (stimulated cells). Here, we show that purified human plasma apoE3 forms a complex with ABCA1 in no