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Autor:
Yan Liu, Richard E. Morton
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 8, Pp 1168-1179 (2020)
J Lipid Res
J Lipid Res
Cholesteryl ester transfer protein (CETP) facilitates the net transfer of cholesteryl esters (CEs) and TGs between lipoproteins, impacting the metabolic fate of these lipoproteins. Previous studies have shown that a CETP antibody can alter CETP's pre
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 11, Pp 1868-1879 (2019)
J Lipid Res
J Lipid Res
Cholesteryl ester transfer protein (CETP) regulates intravascular lipoprotein metabolism. In vitro studies indicate that ApoF alters CETP function by inhibiting its activity with LDL. To explore in vivo the complexities driving ApoF’s effects on CE
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 12, Pp 2349-2359 (2018)
Dietary fat absorption takes place in the intestine, and the liver mobilizes endogenous fat to other tissues by synthesizing lipoproteins that require apoB and microsomal triglyceride transfer protein (MTP). Dietary fat triggers the synthesis of oleo
Autor:
Vesa Kärjä, Jussi Pihlajamäki, Ville Männistö, Dorota Kaminska, Helena Gylling, Marko Simonen, Sari Venesmaa, Pasi Soininen, Mika Ala-Korpela, Mika Tiainen, Antti J. Kangas, Pirjo Käkelä
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 12, Pp 2676-2684 (2014)
Nonalcoholic steatohepatitis (NASH) is associated with increased synthesis of triglycerides and cholesterol coupled with increased VLDL synthesis in the liver. In addition, increased cholesterol content in the liver associates with NASH. Here we stud
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 11, Pp 2408-2415 (2014)
Journal of Lipid Research
Journal of Lipid Research
Reduced plasma LDL-cholesterol is a hallmark of hyperthyroidism and is caused by transcriptional stimulation of LDL receptors in the liver. Here, we investigated whether thyroid hormone (TH) actions involve other mechanisms that may also account for
Autor:
Merit Lagerpusch, Katrin Radloff, Alexander Jaschke, Bart Staels, Bomee Chung, Annette Schürmann, Anne Tailleux, Deike Hesse
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 1, Pp 41-52 (2014)
The liver is a major organ in whole body lipid metabolism and malfunctioning can lead to various diseases including dyslipidemia, fatty liver disease, and type 2 diabetes. Triglycerides and cholesteryl esters are packed in the liver as very low densi
Autor:
Mark J. Graham, Daniel A. Norris, Rosanne M. Crooke, Wuxia Fu, Thomas A. Bell, Adam E. Mullick, Richard G. Lee
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2647-2657 (2013)
Journal of Lipid Research
Journal of Lipid Research
Due to their ability to promote positive effects across all of the lipoprotein classes, cholesteryl ester transfer protein (CETP) inhibitors are currently being developed as therapeutic agents for cardiovascular disease. In these studies, we compared
Autor:
Janet K. Sawyer, Lawrence L. Rudel, Stephanie M. Marshall, Matthew A. Davis, Martha D. Wilson, J. Mark Brown, Kathryn L. Kelley, Jun Zhang, Robert V. Farese
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 6, Pp 1144-1152 (2012)
Acyl-CoA:cholesterol acyltransferase 2 (ACAT2) generates cholesterol esters (CE) for packaging into newly synthesized lipoproteins and thus is a major determinant of blood cholesterol levels. ACAT2 is expressed exclusively in the small intestine and
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 8, Pp 2253-2264 (2010)
Microsomal triglyceride transfer protein (MTP) is required for the assembly and secretion of apolipoprotein (apo) B-containing lipoproteins. Previously, we demonstrated that the N-terminal 1,000 residues of apoB (apoB:1000) are necessary for the init
Autor:
Adam S. Himebauch, David C. Usher, Uwe J. F. Tietge, Cyrille Maugeais, Daniel J. Rader, William Cain, John S. Millar
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 12, Pp 2681-2691 (2005)
Journal of Lipid Research, 46(12), 2681-2691. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Journal of Lipid Research, 46(12), 2681-2691. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
The cellular and molecular mechanisms responsible for lipoprotein [ a] (Lp[a]) catabolism are unknown. We examined the plasma clearance of Lp[ a] and LDL in mice using lipoproteins isolated from human plasma coupled to radiolabeled tyramine cellobios