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Publikováno v:
Journal of Lipid Research, Vol 59, Iss 12, Pp 2349-2359 (2018)
Dietary fat absorption takes place in the intestine, and the liver mobilizes endogenous fat to other tissues by synthesizing lipoproteins that require apoB and microsomal triglyceride transfer protein (MTP). Dietary fat triggers the synthesis of oleo
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 2, Pp 391-399 (2018)
Journal of lipid research, vol 59, iss 2
Journal of lipid research, vol 59, iss 2
Elevated plasma LDL cholesterol is the dominant risk factor for the development of atherosclerosis and cardiovascular disease. Deficiency in the LDL receptor (LDLR) is a major cause of familial hypercholesterolemia in humans, and the LDLR knockout mo
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 12, Pp 2239-2254 (2017)
Alzheimer's disease (AD) is the most common form of dementia in older adults. Currently, there is no cure for AD. The hallmark of AD is the accumulation of extracellular amyloid plaques composed of amyloid-β (Aβ) peptides (especially Aβ1-42) and n
Autor:
Minghui Zhao, Mary J. Lindstrom, Michael A. Polewski, Dhanansayan Shanmuganayagam, Rozalyn M. Anderson, James M. Ntambi, Ricki J. Colman, Maggie S. Burhans
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 8, Pp 1461-1470 (2015)
Journal of Lipid Research
Journal of Lipid Research
Metabolic syndrome is linked with obesity and is often first identified clinically by elevated BMI and elevated levels of fasting blood glucose that are generally secondary to insulin resistance. Using the highly translatable rhesus monkey (Macaca mu
Autor:
Lesley Ann Huggins, Shunichi Homma, Shuiqing Yu, Yunying Hu, Nathan Skoller, Chad M. Trent, Ira J. Goldberg
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 4, Pp 645-658 (2014)
Journal of Lipid Research
Journal of Lipid Research
The rodent heart accumulates TGs and lipid droplets during fasting. The sources of heart lipids could be either FFAs liberated from adipose tissue or FAs from lipoprotein-associated TGs via the action of lipoprotein lipase (LpL). Because circulating
Autor:
Sharon May, Jennifer Chan, Veronica Hirsch-Reinshagen, Sophie Stukas, Cheryl L. Wellington, Nicole DeValle, Michael N. Oda, Jianjia Fan, Charmaine Wong, Anna Wilkinson
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 9, Pp 1605-1616 (2011)
Lipid transport in the brain is coordinated by glial-derived lipoproteins that contain apolipoprotein E (apoE) as their primary protein. Here we show that apoE is secreted from wild-type (WT) primary murine mixed glia as nascent lipoprotein subspecie
Autor:
Ray Truant, Bernardo L. Trigatti, Douglas R. Boreham, Nicole McFarlane, Ayesha M. Ahmed, Yi Zhang, Christina Capone, Suleiman A. Igdoura
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 2, Pp 405-416 (2007)
Scavenger receptor, class B, type I (SR-BI) mediates binding and internalization of a variety of lipoprotein and nonlipoprotein ligands, including HDL. Studies in genetically engineered mice revealed that SR-BI plays an important role in HDL reverse
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 8, Pp 1631-1642 (2006)
Plasma measurements of lipids, lipoproteins, and apolipoproteins provide information on the static levels of these fractions without providing key information on the dynamic fluxes of lipoproteins in the circulation. Kinetics studies, in contrast, pr
Autor:
Klaus G. Parhofer, P. Hugh R. Barrett
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 8, Pp 1620-1630 (2006)
Lipoprotein metabolism is the result of a complex network of many individual components. Abnormal lipoprotein concentrations can result from changes in the production, conversion, or catabolism of lipoprotein particles. Studies in hypolipoproteinemia
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 10, Pp 2052-2060 (2005)
Macrophage foam cells in atherosclerotic lesions accumulate substantial cholesterol stores within large, swollen lysosomes. Previous studies with mildly oxidized low density lipoprotein (OxLDL)-treated THP-1 macrophages suggest an initial buildup of