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Autor:
Apostolos Taxiarchis, Rachel M. Fisher, Hovsep Mahdessian, Ferdinand M. van't Hooft, Angela Silveira
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 6, Pp 1069-1077 (2019)
J Lipid Res
J Lipid Res
Patatin-like phospholipase domain-containing proteins (PNPLAs) are involved in triglyceride hydrolysis and lipid-droplet homeostasis in mice, but the physiological significance of the PNPLAs for triglyceride metabolism in human hepatocytes is unclear
Autor:
Thomas L. Saunders, Yiping Tu, Christopher M. Allan, Norma P. Sandoval, Darren A. Cusanovich, Ty D. Troutman, Loren G. Fong, Anne P. Beigneux, Eniko Sajti, Casey E. Romanoski, Patrick J. Heizer, Jazmin E. Morales, Stephen G. Young, Rachel S. Jung
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 4, Pp 869-879 (2019)
Journal of lipid research, vol 60, iss 4
Journal of lipid research, vol 60, iss 4
Glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1 (GPIHBP1), the protein that shuttles LPL to the capillary lumen, is essential for plasma triglyceride metabolism. When GPIHBP1 is absent, LPL remains stranded within t
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 1, Pp 111-120 (2019)
Journal of Lipid Research
Journal of Lipid Research
We investigated whether, in view of its activity being expressed on both aspects of the endoplasmic reticulum (ER; dual membrane topology), diacylglycerol acyltransferase 1 (DGAT1) plays a distinctive role in determining the triglyceride (TAG) conten
Autor:
Neale D. Ridgway, Jonghwa Lee
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 1940-1950 (2018)
Intracellular lipid droplets (LDs) supply fatty acids for energy, membrane biogenesis, and lipoprotein secretion. The surface monolayer of LDs is composed of phospholipids, primarily phosphatidylcholine (PC), that stabilize the neutral lipid core of
Autor:
Maria Camacho-Hughes, Zhanpin Wu, Robert R. Wolfe, Craig Porter, Labros S. Sidossis, Edgar L. Dillon, Elena Volpi, Rabia Asghar, Heidi Spratt, Clark R. Andersen, Nicola Abate, Maria Chondronikola, Demidmaa Tuvdendorj, Melinda Sheffield-Moore, William J. Durham
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 2018-2024 (2018)
Journal of lipid research, vol 59, iss 10
Journal of lipid research, vol 59, iss 10
Intramyocellular triglyceride (imTG) in skeletal muscle plays a significant role in metabolic health, and an infusion of [(13)C(16)]palmitate can be used to quantitate the in vivo fractional synthesis rate (FSR) and absolute synthesis rate (ASR) of i
Autor:
Jacqueline DeGraaf, Patrick Couture, Seth S. Martin, George Thanassoulis, Patrick R. Lawler, John T. Wilkins, William C. Cromwell, Allan D. Sniderman
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 7, Pp 1266-1275 (2018)
Triglycerides are the conventional tool to measure VLDLs, whereas LDL cholesterol (LDL-C) is the conventional tool to measure LDLs. Multiple epidemiological studies, including a series of genetically based analyses, have demonstrated that cardiovascu
Autor:
Francisca Guardiola-Serrano, Silvia Terés, Ariadna Suari-Rivera, Jesús Casas, Maitane Ibarguren, David J. López, Rafael Álvarez, Or Kakhlon, Xavier Busquets, Pablo V. Escribá, Alexander Lossos
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 8, Pp 1598-1612 (2017)
Adult polyglucosan body disease (APBD) is a neurological disorder characterized by adult-onset neurogenic bladder, spasticity, weakness, and sensory loss. The disease is caused by aberrant glycogen branching enzyme (GBE) (GBE1Y329S) yielding less bra
Autor:
Laurence D. Parnell, Marguerite R. Irvin, Devin Absher, Bertha Hidalgo, Mary K. Wojczynski, Michael A. Province, Stella Aslibekyan, Jose M. Ordovas, Chao-Qiang Lai, Donna K. Arnett
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 12, Pp 2200-2207 (2016)
Journal of Lipid Research
Journal of Lipid Research
Postprandial lipemia (PPL), the increased plasma TG concentration after consuming a high-fat meal, is an independent risk factor for CVD. Individual responses to a meal high in fat vary greatly, depending on genetic and lifestyle factors. However, on
Autor:
Lei Yin, M. Bishr Omary, Pei Li, Neil Gupta, Deqiang Zhang, Xin Tong, Liangyou Rui, Kyle VanDommelen
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 7, Pp 1219-1230 (2016)
Upon food intake, insulin stimulates de novo lipogenesis (DNL) in hepatocytes via the AKT-mTORC1-sterol regulatory element-binding protein (SREBP)-1c pathway. How insulin maintains the maximal SREBP-1c activities during the entire feeding state remai
Autor:
Mengdi Fan, Dajin Zou, Jianxin Lyu, Qingli Ding, Meng-Na Liu, Jun-Nan Xu, Chao Zheng, Dong Liu, Rong Chen, Ye Zhang, Weiping J. Zhang, Gan Liu
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 7, Pp 1155-1161 (2016)
Journal of Lipid Research
Journal of Lipid Research
LPL is a pivotal rate-limiting enzyme to catalyze the hydrolysis of TG in circulation, and plays a critical role in regulating lipid metabolism. However, little attention has been paid to LPL in the adult liver due to its relatively low expression. H