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Progression of chronic kidney disease in familial LCAT deficiency: a follow-up of the Italian cohort
Autor:
Tiziano Lucchi, Tiziana Sampietro, Giuliano Boscutti, Fabrizio Veglia, Alice Ossoli, Loreto Gesualdo, Marcello Arca, Laura Calabresi, Laura D'Erasmo, Chiara Pavanello
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1784-1788 (2020)
J Lipid Res
J Lipid Res
Familial LCAT deficiency (FLD) is a rare genetic disorder of HDL metabolism, caused by loss-of-function mutations in the LCAT gene and characterized by a variety of symptoms including corneal opacities and kidney failure. Renal disease represents the
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 11, Pp 1504-1511 (2020)
J Lipid Res
J Lipid Res
Accompanied with nutrition transition, non-HDL-C levels of individuals in Asian countries has increased rapidly, which has caused the global epicenter of nonoptimal cholesterol to shift from Western countries to Asian countries. Thus, it is critical
Autor:
Naoko Sawada, Toshihiro Aiuchi, Yuji Hamazaki, Rina Kato, Masaki Kikuchi, Shinji Koba, Hiroyuki Itabe, Sanju Iwamoto, Takashi Takaki, Takashi Obama
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 6, Pp 816-829 (2020)
J Lipid Res
J Lipid Res
Oxidized LDL (oxLDL) is a known risk factor for atherogenesis. This study aimed to reveal structural features of oxLDL present in human circulation related to atherosclerosis. When LDL was fractionated on an anion-exchange column, in vivo-oxLDL, dete
Autor:
Yuka Kadomatsu, Yuriko N. Koyanagi, Haruo Mikami, Michiaki Kubo, Mariko Naito, Norihiro Furusyo, Yuichiro Nishida, Asahi Hishida, Yoichi Sutoh, Atsushi Shimizu, Megumi Hara, Mineko Tsukamoto, Toshiro Takezaki, Teruhide Koyama, Chisato Shimanoe, Sakurako Katsuura-Kamano, Kenji Wakai, Tsuyoshi Hachiya, Yukihide Momozawa, Hirokazu Uemura, Naoyuki Takashima, Sadao Suzuki, Isao Oze, Rie Ibusuki, Kiyonori Kuriki, Aya Kadota, Hiroaki Ikezaki, Keitaro Tanaka, Yohko Nakamura, Masahiro Nakatochi, Nagato Kuriyama, Hiroko Nakagawa-Senda
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 1, Pp 86-94 (2020)
J Lipid Res
J Lipid Res
Few studies have investigated the interactions between HDL-C-related SNPs identified by genome-wide association (GWA) study and physical activity (PA) on HDL-C. First, we conducted a sex-stratified GWA study in a discovery sample (2,231 men and 2,431
Autor:
Daisuke Saigusa, Anna Iwahori, Yoshikatsu Eto, Hiroshi Nittono, Hiroaki Yamaguchi, Peter E. Clayton, Isamu Jinnoh, Torayuki Okuyama, Nariyasu Mano, Aya Narita, Takashi Iida, Masamitsu Maekawa, Kousaku Ohno
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 12, Pp 2074-2081 (2019)
J Lipid Res
J Lipid Res
Niemann-Pick disease type C (NPC) is an autosomal recessive disorder characterized by progressive nervous degeneration. Because of the diversity of clinical symptoms and onset age, the diagnosis of this disease is difficult. Therefore, biomarker test
Autor:
Calvin Yeang, Marlys L. Koschinsky, Nicholas J. Viney, Joseph L. Witztum, Sotirios Tsimikas, Tanya T. Marar, Shuting Xia, Michael B. Boffa
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 12, Pp 2082-2089 (2019)
J Lipid Res
Journal of lipid research, vol 60, iss 12
J Lipid Res
Journal of lipid research, vol 60, iss 12
It is postulated that lipoprotein (a) [Lp(a)] inhibits fibrinolysis, but this hypothesis has not been tested in humans due to the lack of specific Lp(a) lowering agents. Patients with elevated Lp(a) were randomized to antisense oligonucleotide [IONIS
Autor:
Franco Bernini, Maria Pia Adorni, Francesca Zimetti, Daniela Galimberti, Paolo Caffarra, Cinzia Marchi, Marco Spallazzi, Nicoletta Ronda, Federica Barocco
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 8, Pp 1449-1456 (2019)
J Lipid Res
J Lipid Res
HDL-like particles in human cerebrospinal fluid (CSF) promote the efflux of cholesterol from astrocytes toward the neurons that rely on this supply for their functions. We evaluated whether cell cholesterol efflux capacity of CSF (CSF-CEC) is impaire
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 6, Pp 1136-1143 (2019)
J Lipid Res
J Lipid Res
BMI is correlated with circulating metabolites, but few studies discuss other adiposity measures, and little is known about metabolomic correlates of BMI from early life. We investigated associations between different adiposity measures, BMI from chi
Autor:
Guenter Fauler, Elisabeth Steinhagen-Thiessen, Bediha Bölükbasi, Ulrich Laufs, Lars K. Steiner, Ursula Kassner, Hubert Scharnagl, Winfried März, Tim Hollstein, Tatjana Stojakovic, Guenther Silbernagel, Friederike Schumann
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 1, Pp 161-167 (2019)
Very few studies have investigated the interrelations between proprotein convertase subtilisin/kexin type 9 (PCSK9) metabolism, cholesterol synthesis, and cholesterol absorption. We aimed to address this issue in a large clinical trial of 245 patient
Autor:
Maria Camacho-Hughes, Zhanpin Wu, Robert R. Wolfe, Craig Porter, Labros S. Sidossis, Edgar L. Dillon, Elena Volpi, Rabia Asghar, Heidi Spratt, Clark R. Andersen, Nicola Abate, Maria Chondronikola, Demidmaa Tuvdendorj, Melinda Sheffield-Moore, William J. Durham
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 2018-2024 (2018)
Journal of lipid research, vol 59, iss 10
Journal of lipid research, vol 59, iss 10
Intramyocellular triglyceride (imTG) in skeletal muscle plays a significant role in metabolic health, and an infusion of [(13)C(16)]palmitate can be used to quantitate the in vivo fractional synthesis rate (FSR) and absolute synthesis rate (ASR) of i