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pro vyhledávání: ''
Autor:
Bruce D. Hammock, Bodgan Barnych, Sean D. Kodani, Lukas Schlatt, Anthony G. Passerini, Amy A. Rand, Todd R. Harris, Anita Rajamani
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 12, Pp 1996-2005 (2019)
Journal of lipid research, vol 60, iss 12
J Lipid Res
Journal of lipid research, vol 60, iss 12
J Lipid Res
Epoxyeicosatrienoic acids (EETs) are formed from the metabolism of arachidonic acid by cytochrome P450s. EETs promote angiogenesis linked to tumor growth in various cancer models that is attenuated in vivo by cyclooxygenase 2 (COX-2) inhibitors. This
Autor:
Ashley J. Snider, Nicholas U. Schwartz, Justin Snider, Christopher J. Clarke, Yusuf A. Hannun, Magali Trayssac, Chiara Luberto, Lina M. Obeid
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 4, Pp 819-831 (2019)
J Lipid Res
J Lipid Res
Sphingolipids (SLs) have been implicated in numerous important cellular biologies; however, their study has been hindered by the complexities of SL metabolism. Furthermore, enzymes of SL metabolism represent a dynamic and interconnected network in wh
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 1, Pp 111-120 (2019)
Journal of Lipid Research
Journal of Lipid Research
We investigated whether, in view of its activity being expressed on both aspects of the endoplasmic reticulum (ER; dual membrane topology), diacylglycerol acyltransferase 1 (DGAT1) plays a distinctive role in determining the triglyceride (TAG) conten
Autor:
Youjia Cao, Ying Liu, Yajun Duan, Ye Zhang, Yuanli Chen, Miao Yu, Xiaoju Li, Xiaoxiao Yang, Jian Liu, Jihong Han, Zhuo Wei, Xingzhe Ma, Chuanrui Ma
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 12, Pp 2287-2296 (2018)
Production of 25-hydroxycholesterol (25HC), a potent inhibitor of viral infection, is catalyzed by cholesterol 25-hydroxylase (CH25H). We previously reported that 25HC induced CH25H expression in a liver X receptor (LXR)-dependent manner, implying th
Autor:
Maria Camacho-Hughes, Zhanpin Wu, Robert R. Wolfe, Craig Porter, Labros S. Sidossis, Edgar L. Dillon, Elena Volpi, Rabia Asghar, Heidi Spratt, Clark R. Andersen, Nicola Abate, Maria Chondronikola, Demidmaa Tuvdendorj, Melinda Sheffield-Moore, William J. Durham
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 2018-2024 (2018)
Journal of lipid research, vol 59, iss 10
Journal of lipid research, vol 59, iss 10
Intramyocellular triglyceride (imTG) in skeletal muscle plays a significant role in metabolic health, and an infusion of [(13)C(16)]palmitate can be used to quantitate the in vivo fractional synthesis rate (FSR) and absolute synthesis rate (ASR) of i
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 6, Pp 1046-1057 (2018)
Sphingolipids constitute a dynamic metabolic network that interconnects several bioactive molecules, including ceramide (Cer), sphingosine (Sph), Sph 1-phosphate, and Cer 1-phosphate. The interconversion of these metabolites is controlled by a cohort
Autor:
Jean E. Vance
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 6, Pp 923-944 (2018)
This article provides a historical account of the discovery, chemistry, and biochemistry of two ubiquitous phosphoglycerolipids, phosphatidylserine (PS) and phosphatidylethanolamine (PE), including the ether lipids. In addition, the article describes
Autor:
William R. Lagor, Junichiro Tohyama, Daniel J. Rader, Tomoyuki Yasuda, Eleonora Cipollari, Xin Bi, Jeffrey T. Billheimer, John S. Millar, Hannah J Szapary, Takashi Kuwano, Nicholas N. Lyssenko
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 4, Pp 731-741 (2017)
Phospholipid transfer protein (PLTP) may affect macrophage reverse cholesterol transport (mRCT) through its role in the metabolism of HDL. Ex vivo cholesterol efflux capacity and in vivo mRCT were assessed in PLTP deletion and PLTP overexpression mic
Autor:
Andrew Henry Huber, Alan M. Kleinfeld
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 3, Pp 578-585 (2017)
We determined for the first time the profiles of the nine most abundant unbound FFAs (FFAus) in human plasma. Profiles were determined for a standard reference plasma of pooled healthy adults for which the Lipid MAPSMAPS Consortium had determined the
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 11, Pp 2217-2225 (2015)
Tocopherols and tocotrienols are metabolized via hydroxylation and oxidation of their hydrophobic side chain to generate 13′-hydroxychromanols (13′-OHs) and various carboxychromanols, which can be further metabolized by conjugation including sulf