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of 74
pro vyhledávání: ''
Autor:
Graeme I. Lancaster, Denis Sviridov, Nigora Mukhamedova, Takahiro Kameda, Gerard Pernes, Peter J. Meikle, Ryunosuke Ohkawa, Boris L. Vaisman, Andrew J. Murphy, Ayuko Hara, Ying Fu, Michael Ditiatkovski, Shao-Jui Lai, Paul J. Nestel, Alan T. Remaley, Hann Low, Dmitri Sviridov, Minoru Tozuka, Yuna Horiuchi, Mai Sasaoka, Azusa Yamazaki
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1577-1588 (2020)
J Lipid Res
J Lipid Res
Lipoproteins play a key role in transport of cholesterol to and from tissues. Recent studies have also demonstrated that red blood cells (RBCs), which carry large quantities of free cholesterol in their membrane, play an important role in reverse cho
Progression of chronic kidney disease in familial LCAT deficiency: a follow-up of the Italian cohort
Autor:
Tiziano Lucchi, Tiziana Sampietro, Giuliano Boscutti, Fabrizio Veglia, Alice Ossoli, Loreto Gesualdo, Marcello Arca, Laura Calabresi, Laura D'Erasmo, Chiara Pavanello
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1784-1788 (2020)
J Lipid Res
J Lipid Res
Familial LCAT deficiency (FLD) is a rare genetic disorder of HDL metabolism, caused by loss-of-function mutations in the LCAT gene and characterized by a variety of symptoms including corneal opacities and kidney failure. Renal disease represents the
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 11, Pp 1504-1511 (2020)
J Lipid Res
J Lipid Res
Accompanied with nutrition transition, non-HDL-C levels of individuals in Asian countries has increased rapidly, which has caused the global epicenter of nonoptimal cholesterol to shift from Western countries to Asian countries. Thus, it is critical
Autor:
Yan Liu, Richard E. Morton
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 8, Pp 1168-1179 (2020)
J Lipid Res
J Lipid Res
Cholesteryl ester transfer protein (CETP) facilitates the net transfer of cholesteryl esters (CEs) and TGs between lipoproteins, impacting the metabolic fate of these lipoproteins. Previous studies have shown that a CETP antibody can alter CETP's pre
Autor:
Naoko Sawada, Toshihiro Aiuchi, Yuji Hamazaki, Rina Kato, Masaki Kikuchi, Shinji Koba, Hiroyuki Itabe, Sanju Iwamoto, Takashi Takaki, Takashi Obama
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 6, Pp 816-829 (2020)
J Lipid Res
J Lipid Res
Oxidized LDL (oxLDL) is a known risk factor for atherogenesis. This study aimed to reveal structural features of oxLDL present in human circulation related to atherosclerosis. When LDL was fractionated on an anion-exchange column, in vivo-oxLDL, dete
Autor:
Michael A. Province, Hemant K. Tiwari, Bertha Hidalgo, Mary F. Feitosa, Degui Zhi, Paul N. Hopkins, Ingrid B. Borecki, Stella Aslibekyan, Robert J. Straka, Alexis C. Frazier-Wood, Marguerite R. Irvin, Xin Geng, Ping An, Kathleen A. Ryan, Braxton D. Mitchell, Jose M. Ordovas, Vinodh Srinivasasainagendra, Donna K. Arnett, Tushar Dave
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 4, Pp 722-729 (2018)
Our understanding of genetic influences on the response of lipids to specific interventions is limited. In this study, we sought to elucidate effects of rare genetic variants on lipid response to a high-fat meal challenge and fenofibrate (FFB) therap
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 6, Pp 1059-1073 (2016)
HDL composition rather than HDL-cholesterol (HDL-C) levels seems to be a key determinant of HDL-induced atheroprotection. Heterozygous familial hypercholesterolemia (FH) patients, with lifelong exposure to high LDL levels, show a high prevalence of p
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 8, Pp 1633-1639 (2015)
At a given level of serum cholesterol, patients with T2D have an increased risk of developing atherosclerosis compared with nondiabetic subjects. We hypothesized that T2D patients have an increased interstitial fluid (IF)-to-serum gradient ratio for
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 8, Pp 1531-1542 (2015)
Serum amyloid A (SAA) is an acute-phase protein that circulates mainly on plasma HDL. SAA interactions with its functional ligands and its pathogenic deposition in reactive amyloidosis depend, in part, on the structural disorder of this protein and i
Autor:
Seth G. Thacker, Maureen Sampson, Heidi L. Collins, Xueting Jin, Lita A. Freeman, Xavier Rousset, Steven J. Adelman, Howard S. Kruth, Safiya Esmail, Boris L. Vaisman, Stephen J. Demosky, Daniela Malide, John A. Stonik, Abdalrahman Zarzour, Alan T. Remaley
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 7, Pp 1282-1295 (2015)
LCAT, a plasma enzyme that esterifies cholesterol, has been proposed to play an antiatherogenic role, but animal and epidemiologic studies have yielded conflicting results. To gain insight into LCAT and the role of free cholesterol (FC) in atheroscle