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Autor:
Mark J. Graham, Daniel A. Norris, Rosanne M. Crooke, Wuxia Fu, Thomas A. Bell, Adam E. Mullick, Richard G. Lee
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2647-2657 (2013)
Journal of Lipid Research
Journal of Lipid Research
Due to their ability to promote positive effects across all of the lipoprotein classes, cholesteryl ester transfer protein (CETP) inhibitors are currently being developed as therapeutic agents for cardiovascular disease. In these studies, we compared
Autor:
Angeliki Chroni, Dimitra Georgiadou, Efstratios Stratikos, Donald L. Gantz, Eleni K. Efthimiadou, George Kordas, Kostas Stamatakis
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 1, Pp 164-176 (2013)
Lipoprotein glomerulopathy (LPG) is a dominant inherited kidney disorder characterized by lipoprotein thrombi in glomerular capillaries. Single-amino-acid mutations in apoE have been associated with the development of the disease, although the mechan
Autor:
Elisabet Wirfält, Bo Hedblad, Sophie Hellstrand, Bo Gullberg, Emily Sonestedt, Marju Orho-Melander, Ulrika Ericson
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 6, Pp 1183-1189 (2012)
Journal of Lipid Research
Journal of Lipid Research; 53(6), pp 1183-1189 (2012)
Journal of Lipid Research
Journal of Lipid Research; 53(6), pp 1183-1189 (2012)
Polymorphisms of the FA desaturase (FADS) gene cluster have been associated with LDL, HDL, and triglyceride concentrations. Because FADS converts alpha-linolenic acid (ALA) and linoleic acid into PUFAs, we investigated the interaction between differe
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 2, Pp 383-388 (2011)
Simple and precise methods for LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) measurements are essential for assessment of cardiovascular disease (CVD) risks and for lipid and lipoprotein studies. We report here an ultracentrifugation (UC) and H
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 8, Pp 2032-2057 (2010)
Plasma levels of HDL cholesterol (HDL-C) have a strong inherited basis with heritability estimates of 40-60%. The well-established inverse relationship between plasma HDL-C levels and the risk of coronary artery disease (CAD) has led to an extensive
Autor:
Srinivasa T. Reddy, Brian J. Van Lenten, Gattadahalli M. Anantharamaiah, Alan M. Fogelman, Susan Hama, Mohamad Navab, Alan C. Wagner
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 11, Pp 2344-2353 (2007)
Rabbits on a 1% cholesterol diet received injections of vehicle with or without D-4F or L-4F. After 1 month, the percent of aorta with atherosclerotic lesions was 24 +/- 15% (vehicle), 10 +/- 6% (D-4F) (P0.01 vs. vehicle), and 13 +/- 9% (L-4F) (P0.05
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 12, Pp 2586-2594 (2005)
Endothelial lipase (EL) is a determinant of high density lipoprotein-cholesterol (HDL-C) level, which is negatively correlated with atherosclerosis susceptibility. We found no difference in aortic atherosclerotic lesion areas between 26-week-old EL+/
Autor:
Medha Manchekar, Nassrin Dashti, Gattadahalli M. Anantharamaiah, Geeta Datta, Manjula Chaddha
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 10, Pp 1919-1928 (2004)
Class A peptides inhibit atherosclerosis and protect cells from class L peptide-mediated lysis. Because the cytolytic process is concentration dependent, we hypothesized that at certain concentrations both classes of peptides exert similar effect(s)
Autor:
Zoe V. Goodger, Mirta Mihovilovic, Jennifer B. Robinette, Ann M. Saunders, Patrick Sullivan, Warren J. Strittmatter, Robert M. DeKroon
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 8, Pp 1566-1573 (2003)
Endothelial cell apoptosis can be initiated by withdrawing growth factors or serum, and is inhibited by HDL. Our results show that the total lipoprotein population from apolipoprotein E 4/4 (APOE4/4) sera is less anti-apoptotic than total lipoprotein
Autor:
Silvia Santamarina-Fojo, Marcelo Amar, Nicholas Duverger, Alan T. Remaley, Federica Basso, H. Bryan Brewer, Edward B. Neufeld, Catherine L. Knapper, John A. Stonik, Terese Tansey, Lita A. Freeman, Jamila Fruchart-Najib
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 2, Pp 296-302 (2003)
The current model for reverse cholesterol transport proposes that HDL transports excess cholesterol derived primarily from peripheral cells to the liver for removal. However, recent studies in ABCA1 transgenic mice suggest that the liver itself may b