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Autor:
Apostolos Taxiarchis, Rachel M. Fisher, Hovsep Mahdessian, Ferdinand M. van't Hooft, Angela Silveira
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 6, Pp 1069-1077 (2019)
J Lipid Res
J Lipid Res
Patatin-like phospholipase domain-containing proteins (PNPLAs) are involved in triglyceride hydrolysis and lipid-droplet homeostasis in mice, but the physiological significance of the PNPLAs for triglyceride metabolism in human hepatocytes is unclear
Autor:
Maria Camacho-Hughes, Zhanpin Wu, Robert R. Wolfe, Craig Porter, Labros S. Sidossis, Edgar L. Dillon, Elena Volpi, Rabia Asghar, Heidi Spratt, Clark R. Andersen, Nicola Abate, Maria Chondronikola, Demidmaa Tuvdendorj, Melinda Sheffield-Moore, William J. Durham
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 2018-2024 (2018)
Journal of lipid research, vol 59, iss 10
Journal of lipid research, vol 59, iss 10
Intramyocellular triglyceride (imTG) in skeletal muscle plays a significant role in metabolic health, and an infusion of [(13)C(16)]palmitate can be used to quantitate the in vivo fractional synthesis rate (FSR) and absolute synthesis rate (ASR) of i
Autor:
Michael A. Province, Hemant K. Tiwari, Bertha Hidalgo, Mary F. Feitosa, Degui Zhi, Paul N. Hopkins, Ingrid B. Borecki, Stella Aslibekyan, Robert J. Straka, Alexis C. Frazier-Wood, Marguerite R. Irvin, Xin Geng, Ping An, Kathleen A. Ryan, Braxton D. Mitchell, Jose M. Ordovas, Vinodh Srinivasasainagendra, Donna K. Arnett, Tushar Dave
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 4, Pp 722-729 (2018)
Our understanding of genetic influences on the response of lipids to specific interventions is limited. In this study, we sought to elucidate effects of rare genetic variants on lipid response to a high-fat meal challenge and fenofibrate (FFB) therap
Autor:
Jacqueline DeGraaf, Patrick Couture, Seth S. Martin, George Thanassoulis, Patrick R. Lawler, John T. Wilkins, William C. Cromwell, Allan D. Sniderman
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 7, Pp 1266-1275 (2018)
Triglycerides are the conventional tool to measure VLDLs, whereas LDL cholesterol (LDL-C) is the conventional tool to measure LDLs. Multiple epidemiological studies, including a series of genetically based analyses, have demonstrated that cardiovascu
Autor:
Laurence D. Parnell, Marguerite R. Irvin, Devin Absher, Bertha Hidalgo, Mary K. Wojczynski, Michael A. Province, Stella Aslibekyan, Jose M. Ordovas, Chao-Qiang Lai, Donna K. Arnett
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 12, Pp 2200-2207 (2016)
Journal of Lipid Research
Journal of Lipid Research
Postprandial lipemia (PPL), the increased plasma TG concentration after consuming a high-fat meal, is an independent risk factor for CVD. Individual responses to a meal high in fat vary greatly, depending on genetic and lifestyle factors. However, on
Autor:
Michael S. Pepper, Fiona A. van Vollenstee, Carla Dessels, Danielle de Villiers, Karlien Kallmeyer, Chrisna Durandt, Candice Murdoch, Marnie Potgieter
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 4, Pp 729-742 (2016)
Journal of Lipid Research
Journal of Lipid Research
The ability of mesenchymal stromal cells (MSCs) to differentiate into adipocytes provides a cellular model of human origin to study adipogenesis in vitro. One of the major challenges in studying adipogenesis is the lack of tools to identify and monit
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 3, Pp 489-501 (2015)
The intestine plays a prominent role in the biosynthesis of triacylglycerol (triglyceride; TAG). Digested dietary TAG is repackaged in the intestine to form the hydrophobic core of chylomicrons, which deliver metabolic fuels, essential fatty acids, a
Autor:
Alan F. Hofmann, Lee R. Hagey
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 8, Pp 1553-1595 (2014)
During the last 80 years there have been extraordinary advances in our knowledge of the chemistry and biology of bile acids. We present here a brief history of the major achievements as we perceive them. Bernal, a physicist, determined the X-ray stru
Autor:
Zhao-Yan Jiang, Mats Eriksson, Camilla Pramfalk, Tiffany A. Melhuish, David Wotton, Paolo Parini
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 4, Pp 709-717 (2014)
Acat2 [gene name: sterol O-acyltransferase 2 (SOAT2)] esterifies cholesterol in enterocytes and hepatocytes. This study aims to identify repressor elements in the human SOAT2 promoter and evaluate their in vivo relevance. We identified TG-interacting
Autor:
Christopher W. Kuzawa, Yun Li, Linda S. Adair, Jin Li, Damien C. Croteau-Chonka, Karen L. Mohlke, Alan B. Feranil, Amanda F. Marvelle, Ying Wu
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 11, Pp 3198-3205 (2013)
Blood levels of lipoprotein cholesterol and triglycerides (TGs) are highly heritable and are major risk factors for cardiovascular disease (CVD). Approximately 100 lipid-associated loci have been identified in populations of European ancestry. We per