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Autor:
Sharon May, Jennifer Chan, Veronica Hirsch-Reinshagen, Sophie Stukas, Cheryl L. Wellington, Nicole DeValle, Michael N. Oda, Jianjia Fan, Charmaine Wong, Anna Wilkinson
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 9, Pp 1605-1616 (2011)
Lipid transport in the brain is coordinated by glial-derived lipoproteins that contain apolipoprotein E (apoE) as their primary protein. Here we show that apoE is secreted from wild-type (WT) primary murine mixed glia as nascent lipoprotein subspecie
Autor:
ZhongMao Guo, J. Shawn Goodwin, Chakradhari Sharan, Gregory A. Grabowski, Hong Yang, LiChun Zhou, DongFang Wu, Hong Du
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 12, Pp 2571-2578 (2007)
Apolipoprotein E (apoE) deficiency has been suggested to induce foam cell formation. Using lipoproteins obtained from wild-type mice and apoE-deficient mice expressing apoB-48 but not apoB-100, we studied apoE-deficient lipoprotein-induced changes in
Autor:
Adam S. Himebauch, David C. Usher, Uwe J. F. Tietge, Cyrille Maugeais, Daniel J. Rader, William Cain, John S. Millar
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 12, Pp 2681-2691 (2005)
Journal of Lipid Research, 46(12), 2681-2691. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Journal of Lipid Research, 46(12), 2681-2691. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
The cellular and molecular mechanisms responsible for lipoprotein [ a] (Lp[a]) catabolism are unknown. We examined the plasma clearance of Lp[ a] and LDL in mice using lipoproteins isolated from human plasma coupled to radiolabeled tyramine cellobios
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 12, Pp 2586-2594 (2005)
Endothelial lipase (EL) is a determinant of high density lipoprotein-cholesterol (HDL-C) level, which is negatively correlated with atherosclerosis susceptibility. We found no difference in aortic atherosclerotic lesion areas between 26-week-old EL+/
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 10, Pp 2214-2220 (2005)
Chylomicron remnants have been suggested to be involved in the development of atherosclerosis. To investigate the mechanisms of chylomicron remnant-induced atherosclerosis, we prepared cholesterol (Chol)-containing emulsion particles as models for ch
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 8, Pp 1572-1579 (2004)
The effect of frozen storage on lipoprotein distribution of apolipoprotein C-III (apoC-III) and apoE was investigated by measuring apoC-III and apoE by ELISA in HDL and apoB-containing lipoproteins of human plasma samples (n = 16) before and after 2
Autor:
Zoe V. Goodger, Mirta Mihovilovic, Jennifer B. Robinette, Ann M. Saunders, Patrick Sullivan, Warren J. Strittmatter, Robert M. DeKroon
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 8, Pp 1566-1573 (2003)
Endothelial cell apoptosis can be initiated by withdrawing growth factors or serum, and is inhibited by HDL. Our results show that the total lipoprotein population from apolipoprotein E 4/4 (APOE4/4) sera is less anti-apoptotic than total lipoprotein
Autor:
Frances M. Platt, David Harvey, Roland Stocker, David A. Priestman, Brett Garner, Terry D. Butters
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 2, Pp 205-214 (2002)
The apolipoprotein E gene knockout (apoE−/−) mouse develops atherosclerosis that shares many features of human atherosclerosis. Increased levels of glycosphingolipid (GSL) have been reported in human atherosclerotic lesions; however, GSL levels h
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 8, Pp 1239-1249 (2001)
Apolipoprotein (apo) E and apoC-III concentrations in VLDL and LDL are associated with coronary heart disease. We studied the relationship between apoE and apoC-III and the abnormal concentrations and distribution of apoB lipoproteins in 10 hyperchol
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 11, Pp 1858-1871 (2000)
Apolipoprotein E (apoE) is the primary recognition signal on triglyceride-rich lipoproteins responsible for interacting with low density lipoprotein (LDL) receptors and LDL receptor-related protein (LRP). It has been shown that lipoprotein lipase (LP