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pro vyhledávání: ''
Autor:
Calvin Yeang, Marlys L. Koschinsky, Nicholas J. Viney, Joseph L. Witztum, Sotirios Tsimikas, Tanya T. Marar, Shuting Xia, Michael B. Boffa
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 12, Pp 2082-2089 (2019)
J Lipid Res
Journal of lipid research, vol 60, iss 12
J Lipid Res
Journal of lipid research, vol 60, iss 12
It is postulated that lipoprotein (a) [Lp(a)] inhibits fibrinolysis, but this hypothesis has not been tested in humans due to the lack of specific Lp(a) lowering agents. Patients with elevated Lp(a) were randomized to antisense oligonucleotide [IONIS
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 11, Pp 2408-2415 (2014)
Journal of Lipid Research
Journal of Lipid Research
Reduced plasma LDL-cholesterol is a hallmark of hyperthyroidism and is caused by transcriptional stimulation of LDL receptors in the liver. Here, we investigated whether thyroid hormone (TH) actions involve other mechanisms that may also account for
Autor:
Huda Salem, Nathalie Saint-Pierre, May Faraj, Alexis Baass, Hanny Wassef, Robert Dufour, Annie Tardif, Simon Bissonnette
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 5, Pp 1466-1476 (2013)
Delayed clearance of triglyceride-rich lipoprotein (TRL) by white adipose tissue (WAT) promotes hypertriglyceridemia and elevated apoB-lipoproteins, which are primarily in the form of LDL. This study examines whether LDL promotes delayed clearance of
Autor:
James V. Pottala, William S. Harris, Susan N. Hansen, Gregory C. Shearer, Verdayne R. Brandenburg
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 11, Pp 2429-2435 (2012)
Journal of Lipid Research
Journal of Lipid Research
The metabolic syndrome includes both dyslipidemia and impaired vascular function. Because extended-release niacin (ERN) and prescription omega-3 acid ethyl-esters (P-OM3) independently improve these characteristics, we tested their effects in combina
Autor:
Barbara Rembiesa, Samar M. Hammad, Jacek Bielawski, Kent J. Smith, Alicja Bielawska, Yusuf A. Hannun, Jason S. Pierce, Farzan Soodavar, Richard L. Klein, Mohammed M. Al Gadban
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 10, Pp 3074-3087 (2010)
We used a HPLC-MS/MS methodology for determination of a basic metabolomic profile (18:1,18:0 sphingoid backbone, C(14)-C(26) N-acyl part) of "normal" sphingolipid levels in human serum and plasma. Blood was collected from healthy males and nonpregnan
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 3, Pp 574-585 (2009)
The Journal of Lipid Research
The Journal of Lipid Research; Vol 50
The Journal of Lipid Research
The Journal of Lipid Research; Vol 50
Glycerophospholipid and sphingolipid species and their bioactive metabolites are important regulators of lipoprotein and cell function. The aim of the study was to develop a method for lipid species profiling of separated lipoprotein classes. Human s
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 9, Pp 2086-2095 (2007)
Isotopic tracer methods of determining triglyceride-rich lipoprotein (TRL) kinetics are costly, time-consuming, and labor-intensive. This study aimed to develop a simpler and cost-effective method of obtaining TRL kinetic data, based on the fact that
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 8, Pp 1772-1780 (2007)
Apolipoprotein M (apoM) is a 188 amino acid, 25 kDa protein belonging to the lipocalin protein superfamily. Although predominantly associated with high density lipoprotein, apoM is found in all major lipoprotein classes. To facilitate clinical studie
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 11, Pp 2193-2201 (2003)
A preponderance of small, dense (sd) LDL is strongly associated with the development of coronary heart disease, but the method for the measurement of sd LDL is too laborious for clinical use. We report a simple method for the quantification of sd LDL
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 11, Pp 2125-2133 (1999)
Scopus-Elsevier
Scopus-Elsevier
Human serum lipoproteins are currently defined according to their density as well as according to their electrophoretic mobility. They can be fractionated into discrete subspecies which exhibit variations in their structure and function. Capillary el